The study of impurities effect on the growth and nucleation kinetics of potassium dihydrogen phosphate

Podder, Jiban

doi:10.1016/s0022-0248(01)01854-1

Cited by 69 publications

(30 citation statements)

References 7 publications

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“…It has been reported that this due to its ability to disrupt the formation and growth of the critical nucleus [3,8]. Impurities have been reported both to suppress and occasionally to accelerate crystal growth processes [9]. N-phosphonomethyl phosphoric acid (PMG) crystallisation is reported to be affected by the impurities, iminobismethylene phosphonic acid and amino methyl phosphoric acid by selective absorption onto the (100) face inhibiting the growth of this face; while the impurity N-phosphonomethyl iminodiacetic acid (PIDA) does not change crystal habit noticeably [10].…”

Section: Introductionmentioning

confidence: 99%

“…Also, an impurity has been reported to affect the solution-mediated phase transformation of the metastable A form to the stable B form of an active pharmaceutical ingredient [11]. The presence of impurities is widely reported to influence crystal growth and crystal morphology [9,[12][13][14][15]. This is the case for amino acids on the habit of glycine crystals [16], or urea crystallisation in the presence of biuret [15].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size distribution determined by Focused Beam Reflectance Measurement (FBRM), crystal habit, filtration rate and impurity content in the crystal product by Liquid Chromatography-Mass Spectroscopy (LC-MS)) were investigated in bulk suspension crystallisation experiments with and without the use of ultrasound. The results demonstrate that ultrasonic intervention has a significant effect on both crystallisation and product crystal properties. It increases the nucleation rate resulting in smaller particles and a narrower Particle Size Distribution (PSD), the yield has been shown to be increase as has the product purity. The effect of ultrasound is to reduce the level acetanilide impurity incorporated during growth from a 2 mol% solution of the selected impurity from 0.85 mol% to 0.35 mol% and likewise ultrasound reduces the uptake of metacetamol from 1.88 mol% to 1.52 mol%.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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“…The growth promoting effect is observed in the presence of organic additives. In recent years, efforts have been taken to improve the quality, growth rate and properties of ADP, by employing new growth techniques, and also by the addition of organic, inorganic and semiorganic impurities [11][12][13][14]. In the light of the research work being done on ADP crystals, to improve the properties, the present work focuses on boron as a dopant in ADP and this is expected to enhance the nonlinearity of the crystal.…”

Section: Introductionmentioning

confidence: 99%

Dielectric and Optical Characterization of Boron Doped Ammonium Dihydrogen Phosphate

Zion¹,

Devarajan²,

Arunachalam³

2013

JCPT

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Single crystals of pure and boron doped ammonium dihydrogen phosphate were grown from aqueous solution by slow solvent evaporation process. ICP studies were done to confirm the presence of the dopant boron in the parent crystal. The values of the lattice parameters were determined by single crystal X-ray diffraction. The pure and doped ADP crystals were found to have tetragonal structure. Complete optical characterizations of the crystals were done using the FTIR, UV-Vis and NLO studies. The presences of the various functional groups in the crystals were identified by FTIR spectrum. The band gap energies of the pure and doped crystals have been calculated at their cut off frequencies using the UV-Vis spectrum. The second harmonic generation efficiency of the crystals was determined. The electric properties of the grown crystal have been analyzed by studying the variation of dielectric constant and dielectric loss with frequency.

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“…Some dopants are added to suppress the effect of metal ion impurities on ADP and KDP crystals. For example, EDTA and KCl reduces the effect of metal ion impurities and enhance the metastable zone width and increases the growth rate of the crystals (Rajesh et al, 2000;Podder 2002;Meenakshisundaram et al, 2009). The addition of such kind of dopants does not remove the impurities present in the solution; it just reacts with the metal ions and is making complexes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Amino Acid Additives on Crystal Growth Parameters and Properties of Ammonium Dihydrogen Phosphate Crystals

Dhanaraj¹,

Rajesh²

2012

Crystallization and Materials Science of Modern Artificial and Natural Crystals

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The study of impurities effect on the growth and nucleation kinetics of potassium dihydrogen phosphate

Cited by 69 publications

References 7 publications

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

Dielectric and Optical Characterization of Boron Doped Ammonium Dihydrogen Phosphate

Effect of Amino Acid Additives on Crystal Growth Parameters and Properties of Ammonium Dihydrogen Phosphate Crystals

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