The Study of Gonadal Hormonal Abnormalities and Sexual Dysfunction in HIV Positive Females: An Exploratory Study

Muthiah, Bhanukumar; Kallikadavil, Abithraj; Shivaswamy, Rajendraprasad; Menon, Vineetha Bharathan

doi:10.7860/jcdr/2016/18992.7581

Cited by 6 publications

(19 citation statements)

References 13 publications

(1 reference statement)

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“…As compared with women with other chronic conditions such as diabetes mellitus and systemic sclerosis, the present study participants had lower overall and domain FSFI scores. However, a few studies have reported FSFI scores that were similar or lower than the present values.…”

Section: Discussioncontrasting

confidence: 50%

“…The prevalence of FSD observed in the present study is among the highest reported, especially by comparison with HIV‐negative women, and with HIV‐positive women in both resource‐rich and resource‐limited settings, but is similar to that among women with other chronic medical conditions . Given the high burden of FSD among this specific group of women, the need for in‐depth studies to explore the interactions of coexisting medical conditions with sexual function cannot be overstated.…”

Section: Discussionmentioning

confidence: 43%

“…There was also no significant association between FSD and HAART use, HIV viral load, or time since HIV diagnosis. Prior studies have reported stronger associations between HIV‐related indices and FSD, with women with HIV infection and FSD having a lower CD4+ cell count, longer duration of infection, higher occurrence of lipodystrophy, and lower adherence to antiretroviral drugs than other women . Given the limited data on FSD in Sub‐Saharan Africa, where individuals with HIV infection are primarily women of reproductive age, further research is needed to help clarify these inconsistent findings.…”

Section: Discussionmentioning

confidence: 98%

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Sexual dysfunction and its determinants among women infected with HIV

Agaba

Meloni

Sule

et al. 2017

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 98%

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Sexual dysfunction and its determinants among women infected with HIV

Agaba

Meloni

Sule

et al. 2017

Intl J Gynecology & Obste

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“…In addition, structural integrity of the testis is essential for maintenance of the hormonal equilibrium including testosterone production. Therefore, with altered androgen levels linked to HAART protocols (Adana et al, ; Muthiah, Kallikadavil, Shivaswamy, & Menon, ), fertility issues become very rife in men on HAART.…”

Section: Introductionmentioning

confidence: 99%

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

et al. 2018

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Human immunodeficiency virus-infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into-A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinising hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it promises to be a beneficial adjuvant for mitigating HAART testicular and reproductive perturbations.

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“…The differences may reflect medical and psychological factors, especially in socioeconomic; cultural; and ethnic differences; the definition used for each type of dysfunction; the type of study tool, the method of data collection; samples; and characteristics of populations studied. 23–25, 45–49 In addition, the observed higher prevalence in our setting and sub-Saharan Africa may be due to cultural differences in the settings or reluctance of women in the sub-Saharan region to talk openly about sex and seek solutions for their sexual concerns. 21,23–25, 45–49 The various explanations for the observed differences have also made generalization and comparison of studies challenging.…”

Section: Discussionmentioning

confidence: 79%

Sexual dysfunction among Nigerian women living with HIV infection

Ezechi,

Akinsolu,

Gbajabiamila

et al. 2023

Preprint

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Introduction Sexual dysfunction in women with HIV is a necessary but understudied aspect of HIV complications in women living with HIV. This study reports the prevalence, pattern, and risk factors for sexual dysfunction in women living with HIV in southwest Nigeria. Methods A validated Female Sexual Function Index was used to determine sexual dysfunction in a cross-sectional study design involving 2926 adult women living with HIV in a large, publicly funded tertiary HIV treatment centre in Lagos, Nigeria. A score of less than 26.5 indicated sexual dysfunction. Multivariate logistic regression analysis was performed to identify risk factors for sexual dysfunction. P<0.05 was considered statistically significant at a 95% confidence interval (CI). Results The prevalence of sexual dysfunction was 71.4%. The types of dysfunctions detected included disorder of desire (76.8%), sexual arousal (66.0%), orgasm (50.0%), pain (47.2%), lubrication (47.2%), and satisfaction (38.8%). Multivariate analysis showed that menopause (aOR: 2.0; 1.4 – 4.1), PHQ score of 10 and above (aOR: 2.3; 1.7 – 3.2), co-morbid medical conditions (aOR: 1.8; 1.4 – 2.7), use of protease inhibitor-based antiretroviral therapy (aOR: 1.3; 1.2 - 2.1) and non-disclosure of HIV status (aOR: 0.7; 0.6-0.8) were factors associated with sexual dysfunction. Conclusions Sexual dysfunction is common among Nigerian women living with HIV. Menopause, use of protease inhibitor-based regimens, PHQ score of at least 10, co-morbid medical condition, and non-disclosure of HIV status were associated with sexual dysfunction. National HIV programmes, in addition to incorporating screening and management of sexual dysfunction in the guidelines, should sensitise and train health workers on the detection and treatment of sexual dysfunction.

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The Study of Gonadal Hormonal Abnormalities and Sexual Dysfunction in HIV Positive Females: An Exploratory Study

Cited by 6 publications

References 13 publications

Sexual dysfunction and its determinants among women infected with HIV

Sexual dysfunction and its determinants among women infected with HIV

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

Sexual dysfunction among Nigerian women living with HIV infection

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