The Study of Embryotoxic and Teratogenic Effects of Diisononyl Phthalate

Abstract

Toxicological studies were conducted on impact of diisononyl phthalate (DINP) on the reproductive system of white vrats..In experiments, A. Dinerman,’s scheme was applied which allows recording embryotropic and teratogenic effects taking into account the dynamics of the development of offspring in the postnatal period. The presence of anomalies in the development of embryos internal organs was determined by the sagittal section method according to W. Wilson. It was found out that intragastric administration of the test compound to females during the pregnancy period at doses of 100, 1000 and 10,000 mg/kg initiated external and internal malformations in embryos. The exposure level of 10,000 mg/kg is characterized by increased rate of total post implantation and embryonic mortality, multiple embryonic developmental defects. At the same time, there were no significant changes in the postnatal development of the offspring compared to the control. In the experiment it was established that the dose of 10 mg/kg is the most inactive dose of DINP at which no signs of teratogenic and embryotropic actions were revealed.