The study of DMSO/water and DPPC/DMSO/water system by means of the X-ray, neutron small-angle scattering, calorimetry and IR spectroscopy

Shashkov, S. N.; Киселев, М. А.; Tioutiounnikov, S.N.; Kiselev, A.M.; Lesieur, P.

doi:10.1016/s0921-4526(99)00214-8

Cited by 69 publications

(66 citation statements)

References 10 publications

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“…Neutron scattering measurements have shown a slight enrichment of DMSO near the surface, 21 which appears to be in agreement with IR measurements that suggest association of the partially charged atoms of DMSO (i.e., the positive sulfur and the negative oxygen) with either of the oppositely charged head group moieties of the phospholipid head group (i.e., the positive amine/choline and the negative phosphate). 28 In contrast, recent simulations have shown a ∼50% depletion of DMSO near the membrane surface, 29 which has been explained through a stronger preference of DMSO for water than the lipid. Differential vapor pressure and calorimetry measurements suggest that glycerol is preferentially excluded from the surface, and that its binding is thermodynamically unfavorable, 30 while simulations have shown a substantial enrichment.…”

Section: Introductionmentioning

confidence: 94%

Communication: Contrasting effects of glycerol and DMSO on lipid membrane surface hydration dynamics and forces

Schrader

Cheng

Israelachvili

et al. 2016

The Journal of Chemical Physics

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Water structure around hydrophobic amino acid side chain analogs using different water models The Journal of Chemical Physics 146, 225104 (2017) Glycerol and dimethyl sulfoxide (DMSO) are commonly used cryoprotectants in cellular systems, but due to the challenges of measuring the properties of surface-bound solvent, fundamental questions remain regarding the concentration, interactions, and conformation of these solutes at lipid membrane surfaces. We measured the surface water diffusivity at gel-phase dipalmitoylphosphatidylcholine (DPPC) bilayer surfaces in aqueous solutions containing ≤7.5 mol. % of DMSO or glycerol using Overhauser dynamic nuclear polarization. We found that glycerol similarly affects the diffusivity of water near the bilayer surface and that in the bulk solution (within 20%), while DMSO substantially increases the diffusivity of surface water relative to bulk water. We compare these measurements of water dynamics with those of equilibrium forces between DPPC bilayers in the same solvent mixtures. DMSO greatly decreases the range and magnitude of the repulsive forces between the bilayers, whereas glycerol increases it. We propose that the differences in hydrogen bonding capability of the two solutes leads DMSO to dehydrate the lipid head groups, while glycerol affects surface hydration only as much as it affects the bulk water properties. The results suggest that the mechanism of the two most common cryoprotectants must be fundamentally different: in the case of DMSO by decoupling the solvent from the lipid surface, and in the case of glycerol by altering the hydrogen bond structure and intermolecular cohesion of the global solvent, as manifested by increased solvent viscosity. Published by AIP Publishing.[http://dx

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Section: Introductionmentioning

confidence: 94%

Communication: Contrasting effects of glycerol and DMSO on lipid membrane surface hydration dynamics and forces

Schrader

Cheng

Israelachvili

et al. 2016

The Journal of Chemical Physics

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“…[61] Consequently, conclusions regarding DMSO-water hydrogen bonding should apply to DMSOmonosaccharide, and hence DMSO-cellulose interactions. Several pieces of evidence, including theoretical calculations, [62] IR and NMR spectroscopy, [63][64] neutron scattering [65] and electron-spray mass spectroscopy, [66] have shown that DMSO-water interactions are stronger than water-water interactions, and that DMSO forms complexes with one or two water molecules. Recent studies of solvatochromism in binary mixtures of several aprotic solvents with water have shown that DMSO behaves differently, because it forms the strongest hydrogen bond with water.…”

Section: Quantitative Correlations Of Cellulose Swelling By Aprotic Smentioning

confidence: 99%

Cellulose Swelling by Aprotic and Protic Solvents: What are the Similarities and Differences?

Fidale¹,

Ruiz²,

Heinze³

et al. 2008

Macro Chemistry & Physics

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The swelling of microcrystalline, native and mercerized cotton and eucalyptus celluloses by 16 aprotic solvents was investigated. The number of moles of solvent/anhydroglucose unit, nSw, correlates well with solvent molar volume, basicity and dipolarity/polarizability. Swelling is sensitive to cellulose crystallite size, surface area and the presence of its chains in parallel or anti‐parallel arrangements. Use of solvatochromic parameters is a superior alternative to the use of other descriptors, such as Hildebrand's solubility parameters and Gutmann's donor numbers. The calculated nSw for 28 protic and aprotic solvents correlated well with their experimental counterparts, although hydrogen bond donation by the solvent was not included.magnified image

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“…[48] The small magnitudes of φ DMSO-W/W and φ DMSO-W/DMSO may be attributed to the fact that the interaction of DMSO with W attenuates the solvation efficiency of the complex solvent. Several pieces of evidence, including theoretical calculations, [44] IR and 1 H and 13 C NMR spectroscopy, [45,46] neutron scattering, [47] and electron-spray mass spectroscopy, [48] have indicated that the DMSO-W interactions are stronger than W-W interactions. Additionally, a plot of α mixt (acidity of the DMSO-W mixtures) vs. χ DMSO shows negative deviation from linearity; the corresponding plot for β mixt (basicity of the DMSO-W mixtures) shows a positive deviation [60] (i.e., aqueous DMSO is less acidic than expected).…”

Section: Thermo-solvatochromism In Binary Solvent Mixturesmentioning

confidence: 99%

Thermo‐Solvatochromism of Merocyanine Polarity Probes – What Are the Consequences of Increasing Probe Lipophilicity through Annelation?

et al. 2008

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The question raised in the title has been answered by comparing the solvatochromism of two series of polarity probes, the lipophilicities of which were increased either by increasing the length of an alkyl group (R) attached to a fixed pyridine-based structure or through annelation (i.e., by fusing benzene rings onto a central pyridine-based structure). The following novel solvatochromic probes were synthesized:. The solvatochromic behavior of these probes, along with that of 2,6-dibromo-4-[(E)-2-(1-methylpyridinium-4-yl)ethenyl]phenolate (MePMBr 2 ) was analyzed in terms of increasing probe lipophilicity, through annelation. Values of the empirical solvent polarity scale [E T (MePMBr 2 )] in kcal mol -1 correlated linearly with E T (30), the corresponding values for the extensively employed probe 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-1-yl)phenolate (RB). On the other hand, the nonlinear correlations of E T (MeQMBr 2 ) or E T (MeAMBr 2 ) with E T (30) are described by second-order polynomials. Possible reasons for this behavior include: i) self-aggregation of the probe, ii) photoinduced cis/trans isomerization of the dye, and iii) probe structure-and solvent-dependent contributions of the quinonoid and zwitterionic limiting formulas to the ground and excited states of the probe. We show that mechanisms (i) and (ii) are not operative under the experimental conditions employed; experimental evidence (NMR) and theoretical calculations are presented to support the conjec-

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The study of DMSO/water and DPPC/DMSO/water system by means of the X-ray, neutron small-angle scattering, calorimetry and IR spectroscopy

Cited by 69 publications

References 10 publications

Communication: Contrasting effects of glycerol and DMSO on lipid membrane surface hydration dynamics and forces

Communication: Contrasting effects of glycerol and DMSO on lipid membrane surface hydration dynamics and forces

Cellulose Swelling by Aprotic and Protic Solvents: What are the Similarities and Differences?

Thermo‐Solvatochromism of Merocyanine Polarity Probes – What Are the Consequences of Increasing Probe Lipophilicity through Annelation?

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