The study of changes in gene regulation of serotonin signaling pathway and circulating serotonin concentration in dogs with pulmonary hypertension due to degenerative mitral valve disease
Abstract:Pulmonary hypertension (PH) is an abnormal increase in pulmonary vascular pressure. In dogs, PH is commonly found secondary to degenerative mitral valve disease (DMVD), especially in small breed dogs. Serotonin, a biogenic amine playing an essential role in both physiology and abnormalities of several organs, is a vasoactive substance that has been one of the suspicious mediators for the development of PH. Both local and circulating effects of serotonin have been investigated to discover the involvement of ser… Show more
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