The Study and Treatment of 119 Cases of Carcinoma of the Thyroid With Radioactive Iodine*†

The Concentration and Significance of the Butanol-Extractable I131 of Serum in Patients with Diverse States of Thyroidal Function

“…It is not known whether, in these patients the remaining thyroid tissue is normal or neoplastic in character. If it were the latter, then the increased turnover rate could be the result of an inability of the tissue to store iodine because of a structural characteristic, such as absence of follicles (29). It is more likely, however, that the increased turnover rates reflect an intense stimulation of the residual thyroid tissue by thyrotropin (30).…”

AN EVALUATION OF VARIOUS FACTORS INFLUENCING THE TREATMENT OF METASTATIC THYROID CARCINOMA WITH I131*†

“…Blood studies showed positive results with the tourniquet test, a decreased number of white blood cells with a normal differential count, decreased platelets, and a normal bone marrow. 3 External radiation (3,000 r) to the pelvic lesion and 235 me. of I 131 (47.9 per cent excreted in the urine in forty-eight hours) were administered in the next six months.…”

“…Therefore this procedure, which has been effective in increasing the avidity of these metastases for I 131 (1,2,3), is usually carried out prior to radioactive iodine treatment. In increasing the uptake of I 131 by means of surgical total thyroidectomy, growth of metastases inevitably follows (Table 2).…”

Molecular Biology and Functions of Carrier Proteins. Annual Symposium (46th) of the Society of General Physiologists held in Woods Hole, Massachusetts on September 10-13, 1992. Volume 48

“…1989: Werner and Ingbar. 1991 uptake system of the thyroid provides the basis for radioactive iodide therapy, which is used in the treatment of toxic adenomas and thyroid cancer cases in which Iuptake is deemed sufficient to warrant such therapy (Dobyns and Maloof, 1951;DeGroot and Reilly, 1982;Gosdstein and Hart, 1983). Clearly.…”