The studies on the cytotoxicity in vitro, cellular uptake, cell cycle arrest and apoptosis-inducing properties of ruthenium methylimidazole complex [Ru(MeIm)4(p-cpip)]2+

Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines

“…Quantification of Cellular Uptake by ICP‐MS: Quantification of cellular uptake was carried out by ICP‐MS following a modified procedure . Briefly, 1.0 × 10 6 cells (A549) were plated in 60 mm petri dishes and allowed to adhere for 12 h at 37° with 5 % CO 2 .…”

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

“…ROS have been shown to be associated with oxidative stress . Toxic, oxygen free radicals contribute to aging , apoptosis , and pathological processes in many clinical disorders, such as cardiac dysfunction and myocyte injury . More recently, ROS have also been shown to be involved in signaling processes , having a role as signaling molecules that generate specificity in ROS homeostasis.…”

The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex

“…In the last few years, our investigations have been focus on the Ru(II)-imidazole/methylimidazole compounds including their design, synthesis, structural modification, biological activity, and underlying behaviour mechanisms [10–15]. In previous studies, Ru(II) methylimidazole complexes, with the general formula [Ru(MeIm) 4 (L)] 2+ (L = dpq, dppz, iip, tip, cpip), showed strong DNA-binding affinities and some antitumor activities [10–14]. It is worth noting that the homologous complex Ru1 (Figure 1A) bearing imidazole as the ancillary ligand synthesised in our laboratory, differs from other ruthenium (II) methylimidazole complexes in the circular dichroic spectrum of DNA–complex adducts, and so on [10].…”