The structures of syringolides 1 and 2, novel C-glycosidic elicitors from Pseudomonas syringae pv. tomato

Midland, Sharon L.; Keen, N. T.; Sims, James J.; Midland, M. Mark; Stayton, Mark M.; Burton, Vicki; Smith, Morton; Mazzola, Eugene P.; Graham, Kate J.; Clardy, Jon

doi:10.1021/jo00063a007

Cited by 107 publications

(69 citation statements)

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“…Syringolide 1 was obtained from culture fluids of Esckerickia coli expressing the avrD gene and was purified by HPLC on silica gel columns (Midland et al, 1993;Yucel et al, 1994). In some preliminary experiments (not shown), we used a less pure elicitor fraction that contained syringolides 1 and 2.…”

Section: Elicitormentioning

confidence: 99%

“…It has been widely postulated that avirulence genes direct the production of cultivar-specific elicitors that are recognized by plants with the complementary resistance gene (Gabriel and Rolfe, 1990;Keen, 1990;Atkinson, 1993). Severa1 such elicitors have been identified, including the coat protein of tobacco mosaic virus (Culver and Dawson, 1989), a peptide from Cladosporium fulvum (Van den Ackerveken et al, 1992), and glycolipids, called syringolides, from Pseudomonas syringae pv tomato (Midland et al, 1993). Bacterial synthesis of the syringolides is directed by the avirulence gene avrD.…”

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confidence: 99%

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Syringolide 1 Triggers Ca2+ Influx, K+ Efflux, and Extracellular Alkalization in Soybean Cells Carrying the Disease-Resistance Gene Rpg4

et al. 1996

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Section: Elicitormentioning

confidence: 99%

mentioning

confidence: 99%

Syringolide 1 Triggers Ca2+ Influx, K+ Efflux, and Extracellular Alkalization in Soybean Cells Carrying the Disease-Resistance Gene Rpg4

et al. 1996

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“…Among the Ͼ 30 bacterial AVR gene products reported in the literature, only a few have presented clues as to what this function might be. The avrD gene cloned from Pseudomonas syringae pv glycinea is believed to play a role in producing low molecular weight glycolipid elicitors (Keen et al, 1990;Midland et al, 1993). The bacterial AVR gene, avrRxv , 1 Current address: Department of Plant Pathology, University of Arizona, Tucson, AZ.…”

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A Telomeric Avirulence Gene Determines Efficacy for the Rice Blast Resistance Gene Pi-ta

et al. 2000

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Genetic mapping showed that the rice blast avirulence gene AVR-Pita is tightly linked to a telomere on chromosome 3 in the plant pathogenic fungus Magnaporthe grisea . AVR-Pita corresponds in gene-for-gene fashion to the disease resistance ( R ) gene Pi-ta . Analysis of spontaneous avr-pita Ϫ mutants indicated that the gene is located in a telomeric 6.5-kb BglII restriction fragment. Cloning and DNA sequencing led to the identification of a candidate gene with features typical of metalloproteases. This gene is located entirely within the most distal 1.5 kb of the chromosome. When introduced into virulent rice pathogens, the cloned gene specifically confers avirulence toward rice cultivars that contain Pi-ta . Frequent spontaneous loss of AVR-Pita appears to be the result of its telomeric location. Diverse mutations in AVR-Pita , including point mutations, insertions, and deletions, permit the fungus to avoid triggering resistance responses mediated by Pi-ta . A point mutation in the protease consensus sequence abolishes the AVR-Pita avirulence function. INTRODUCTIONRice blast disease, caused by the fungus Magnaporthe grisea (Hebert) Barr (Rossman et al., 1990), remains one of the most important constraints to rice production worldwide, despite the availability of dozens of "major" disease resistance ( R ) genes, which are known as Pi genes (Yamada et al., 1976; Zeigler et al., 1994). Resistance mediated by Pi genes has not been durable, typically failing under field conditions soon after new cultivars are introduced to the field as new races, or pathotypes, of the pathogen appear with the ability to attack the previously resistant rice cultivars. Sasaki first distinguished differences in cultivar specificity between rice blast field isolates in 1922 (Yamada, 1985); since then, hundreds of pathogen races have been identified based on their infection spectra on differential rice cultivars. Recently, DNA fingerprinting analyses have shown that rice blast fungal populations are asexual and consist of dozens of families (discretely separable clonal lineages) having apparently predictable responses toward specific R genes (Levy et al., 1993; Zeigler et al., 1994). Lineage exclusion strategies are currently being tested as an aid for deploying R genes for genetic control of rice blast disease.The rice blast system is a classical gene-for-gene system (Flor, 1971) in which avirulence ( AVR ) genes in the pathogen show a functional correspondence with particular R genes in rice (Silué et al., 1992; Zeigler et al., 1994). AVR genes may encode pathogen molecules that are themselves recognized, directly or indirectly, by the corresponding R gene product, or they may encode enzymes involved in production of small molecule ligands that serve as recognition factors. Pathogen recognition triggers host resistance responses and stops infection. Field efficacy of any R gene thus depends on the biology of its associated AVR gene. Specifically, R gene efficacy depends on the nature of any function that an AVR gene may provide for th...

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“…28 It is noteworthy that the same butenolide compound has been proposed as an intermediate for syringolide biosynthesis in Pseudomonas syringae. 29 Interaction of SCP1 with S. coelicolor chromosome and other replicons SCP1 is known to interact with the S. coelicolor chromosome to generate various SCP1-chromosome hybrid structures. A 1850-kb linear DNA was found in S. coelicolor 2106, a cysD donor, which transfers a cysD phenotype in the mating with an SCP1-free strain.…”

Section: Biosynthesis Of Methylenomycin and Autoregulators In S Coelmentioning

confidence: 99%

Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters

Kinashi

2010

J Antibiot

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Many giant linear plasmids have been isolated from Streptomyces by using pulsed-field gel electrophoresis and some of them were found to carry an antibiotic biosynthetic cluster(s); SCP1 carries biosynthetic genes for methylenomycin, pSLA2-L for lankacidin and lankamycin, and pKSL for lasalocid and echinomycin. Accumulated data suggest that giant linear plasmids have played critical roles in genome evolution and horizontal transfer of secondary metabolism. In this review, I summarize typical examples of giant linear plasmids whose involvement in antibiotic production has been studied in some detail, emphasizing their finding processes and interaction with the host chromosomes. A hypothesis on horizontal transfer of secondary metabolism involving giant linear plasmids is proposed at the end.

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The structures of syringolides 1 and 2, novel C-glycosidic elicitors from Pseudomonas syringae pv. tomato

Cited by 107 publications

References 0 publications

Syringolide 1 Triggers Ca2+ Influx, K+ Efflux, and Extracellular Alkalization in Soybean Cells Carrying the Disease-Resistance Gene Rpg4

Syringolide 1 Triggers Ca2+ Influx, K+ Efflux, and Extracellular Alkalization in Soybean Cells Carrying the Disease-Resistance Gene Rpg4

A Telomeric Avirulence Gene Determines Efficacy for the Rice Blast Resistance Gene Pi-ta

Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters

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