The structure of the Major Histocompatibility Complex of the Chicken

Hála, K; Vilhelmová, M; Hartmanová, Jana

doi:10.1007/978-1-4613-4169-7_21

Cited by 31 publications

(10 citation statements)

References 10 publications

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“…The latter workers suggested a three locus model. Hala et al (1977) elaborated upon this and indicated the existence of three loci, three corresponding antigens, and three chromosomal regions BF, BL, and BG, respectively, in the MHC. Antigens coded by the BF, and mainly the BL, regions strongly influenced the mixed leukocyte reaction (MLR), graft vs. host reaction as determined by splenomegaly or the chorioallantoic membrane (CAM) test, and skin graft rejection.…”

Section: Resultsmentioning

confidence: 96%

“…Antigens coded by the BF, and mainly the BL, regions strongly influenced the mixed leukocyte reaction (MLR), graft vs. host reaction as determined by splenomegaly or the chorioallantoic membrane (CAM) test, and skin graft rejection. The BG region specifies an erythrocyte antigen only and has no effect upon the above reactions (Pink et al, 1977;Hala et al, 1977). Haplotypes resulting from recombination between BF and BG segments of the MHC of two congenic lines possessed erythrocyte antigens of both parental types, but cellular responses to antigens were identical to the parental line from which the BF region was derived .…”

Section: Resultsmentioning

confidence: 97%

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Genetic Nature of Regression of Rous sarcoma Virus-Induced Tumors in Crosses of Regional Poultry Research Laboratory Lines 6 and 72,

et al. 1979

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Regional Poultry Research Laboratory (RPRL) inbred lines 6(1), 6(3), and 7(2) and F1, F2, and reciprocal backcross progenies of these lines were used to investigate host-gene effects upon the regression of Rous sarcoma virus (RSV)-induced tumors. Lines 6(1) and 6(3) were susceptible to subgroup A and C lymphoid leukosis (LL) viruses and line 7(2) was resistant to subgroup A but was segregating for susceptibility to subgroup C LL virus. Viruses of RSV subgroups A and C were used. Lines 6(1), 6(3), and 7(2) were homozygous for shared blood group alleles B2, C5, L1 and r. The incidence of tumor regression was higher in line 6(3) than in 7(2), and in reciprocal F1 crosses of these lines was of the same order of magnitude as in line 6(3). Progeny from F1 generation parents mated to line 6(3) had a higher frequency of regression than offspring from F1 generation parents mated to line 7(2). The frequency of regression in F2 generation offspring was intermediate between the two backcrosses. The data suggest that either a locus (or loci) other than L and B has a role in Rous tumor regression in this species or the immune response region of the B blood group-major histocompatibility complex differs in the two lines even though the serological and/or graft vs. host regions have not been shown to differ.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 97%

Genetic Nature of Regression of Rous sarcoma Virus-Induced Tumors in Crosses of Regional Poultry Research Laboratory Lines 6 and 72,

et al. 1979

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“…The B haplotype is now known to consist of several subloci (26), but, in comparison to the mammalian counterpart MHCs, the frequency of recombination between genes appears very low. We think that (34,35) the immune response to thyroglobulin, or it may be due to other factors that we have previously discussed (35).…”

Section: Discussionmentioning

confidence: 99%

Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens.

Bacon

Rose²

1979

Proc. Natl. Acad. Sci. U.S.A.

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Three partially inbred substrains of Obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histocompatibility complex (B haplotype) was marked in one, less marked but still significant in a second, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.

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“…Haplotypes of the B system of erythrocyte alloantigens, produced by B-F and B-G regional genes (Hala et al, 1977), and C system alloantigens were identified by cross-reactions of the erythrocytes of pedigreed families of the White Plymouth Rock lines with alloimmune reference reagents developed in the NIU colony of chickens. Definitive cross-reactive patterns of four B haplotypes and four C system alloantigens are shown in Table 3.…”

Section: Identification Of B and C Alloantigensmentioning

confidence: 99%

Selection for Body Weight at Eight Weeks of Age.

Boa-Amponsem

Briles

et al. 1992

Poultry Science

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The current study evaluated influence of genotypes of the B and C alloantigen systems on production traits in lines of White Plymouth Rock chickens. Lines had been selected previously for high (HWS) or low (LWS) 8-wk BW and after 27 generations of selection, a random sample of each selected line was used to initiate subpopulations in which selection was relaxed. For the present study, blood typing was used to identify allelic frequencies for the B and C systems for five consecutive generations of selection (Generations 30 through 34) and three consecutive generations of relaxation (Generations 5 through 7). Haplotypes for the B complex were assigned designations B32, B33, B34, and B35 and alleles of the C system were assigned C8, C9, C10, and C11. Production traits for males were BW at 4 and 8 wk of age, and for females were BW at 4, 8, and 38 wk of age, age and BW at production of first egg, percentage of normal eggs, and percentage of normal hen-day egg production. There were no differences in production traits among B genotypes or among C genotypes, although some time trends in gene frequencies suggested that more subtle effects may be present.

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The structure of the Major Histocompatibility Complex of the Chicken

Cited by 31 publications

References 10 publications

Genetic Nature of Regression of Rous sarcoma Virus-Induced Tumors in Crosses of Regional Poultry Research Laboratory Lines 6 and 72,

Genetic Nature of Regression of Rous sarcoma Virus-Induced Tumors in Crosses of Regional Poultry Research Laboratory Lines 6 and 72,

Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens.

Selection for Body Weight at Eight Weeks of Age.

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