The structure of the lung of the newborn marsupial bandicoot,Isoodon macrounus

Gemmell, R. T.; Little, G. J.

doi:10.1007/bf01258501

Cited by 32 publications

(30 citation statements)

References 17 publications

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“…A few studies have described the histological appearance of metatherian lungs (Gemmel, 1986; Gemmell & Little, 1982; Gemmell & Selwood, 1994) but no studies have mentioned BALT until recently (Old et al. 2003a; Young et al.…”

Section: Discussionmentioning

confidence: 99%

The appearance and distribution of mature T and B cells in the developing immune tissues of the stripe‐faced dunnart (Sminthopsis macroura)

2004

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This paper describes the initial appearance and distribution of mature T and B cells in the developing immune tissues of the stripe-faced dunnart ( Sminthopsis macroura ) based on the use of species cross-reactive antibodies to the lymphocyte cell surface markers CD3, CD5 and CD79b. At birth no mature T or B cells were detected in the liver or bone marrow using anti-CD3, anti-CD5 or anti-CD79b antibodies. T cells were detected in the thymus with anti-CD3 by day 12 and anti-CD5 by day 50 postpartum, and T cells in the spleen were detected by day 43 and day 80 postpartum using anti-CD3 and anti-CD5, respectively. B cells were observed in the dunnart spleen by 43 days after birth. CD3-and CD79b-positive cells were detected in the lymph nodes by 50 days and CD5 by day 15 after birth, and in the gut-associated lymphoid tissues by day 50 and anti-CD5 by day 57 postpartum. The development and distribution of T and B cells in the immune tissues of dunnart pouch young is similar to that described in other marsupial species. Low numbers or absence of mature lymphocytes in immune tissues of early pouch young dunnarts further support the proposition that young marsupials are reliant on non-specific defence strategies and/or maternal strategies for a significant period of their time of development in the pouch.

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Section: Discussionmentioning

confidence: 99%

The appearance and distribution of mature T and B cells in the developing immune tissues of the stripe‐faced dunnart (Sminthopsis macroura)

2004

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“…Corticosteroids increase towards term in the fetal plasma of ruminants, small animal species, the pig, and primates (Liggins et al, 1973;Mulay et al, 1973;Challis et al, 1977;Lohse and First, 1981); and this has been shown to be the result of increased secretion from the fetal adrenals in sheep (Liggins et al, 19731, guinea pigs (Jones and Roebuck, 19801, and the pig (Lohse and First, 1981). In the marsupial I. macrourus, a concentration of 0.1 ng per adrenal is observed in the newborn bandicoot (Gemmell et al, 1982). This contrasts with the concentration of 0.58 ng per adrenal in the larger newborn of M. rufogriseus.…”

Section: Discussionmentioning

confidence: 90%

“…Profiles of smooth endoplasmic reticulum indicative of steroid biosynthesis are abundant in the fetal adrenal cells of eutherian mammals (Malamed, 1975), and in such marsupials as the bandicoot Isoodon macrourus (Gemmell et al, 1982). In the tammar, adrenocortical cells have the enzymatic capacity for steroid synthesis five days prior to birth, and this functional capability is established only one day after formation of the gland (Call et al, 1980).…”

Section: Discussionmentioning

confidence: 98%

Organogenesis of the pituitary, adrenal, and lung at birth in the wallaby, Macropus rufogriseus

Walker¹,

Gemmell²

1983

Am. J. Anat.

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The ultrastructure of the pituitary, the adrenal, and the lung was examined in the newborn wallaby, Macropus rufogriseus. Tissue from six wallaby neonates (less than 8 hr of age), two near-term fetuses (26 days after removal of suckling pouch young [RPY]), and a two-day-old pouch young was examined; and tissue levels of cortisol in the adrenal glands of five neonates and a near-term fetus (26 days) were measured by radioimmunoassay. At birth the adenohypophysis comprised the bulk of the pituitary gland. The pars distalis was well vascularized and many cells contained electron-dense, membrane-bound granules. The adrenal glands lacked specific zones but comprised two distinct populations of cells. The cytoplasm of one cell type contained electron-dense, membrane-bound granules, similar to those observed inside catecholamine-secreting cells of the adrenal medulla; the other cell type possessed large amounts of smooth endoplasmic reticulum and mitochondria with tubulo-vesicular cristae. These features are characteristic of cells which are actively synthesizing steroid hormones. The concentration of cortisol was 0.58 ng/adrenal in the wallaby at birth. The fetal lungs near term were at the glandular stage of development, and epithelial differentiation of type I and type II pneumocytes was imminent although attenuation was not evident. The canalicular neonatal lung did not contain true alveoli, but type II pneumocytes contained osmiophilic lamellar inclusions of surfactant. The fetal pituitary and adrenal are functional at birth and are thus capable of initiating parturition and of influencing lung maturation in the fetus.

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“…This was described as having a small intestine lined with tall columnar epithelial cells with centrally located nuclei. Gemmell and Little (1982) and Gemmell (1986) described the developing lungs of the newborn Northern brown bandicoot (Isoodon macrourus) as having air sacs but no alveoli. The newborn lungs of the stripe-faced dunnart (Sminthopsis macroura) were similarly described (Gemmell and Selwood 1994).…”

Section: Discussionmentioning

confidence: 98%

The lymphoid and immunohaematopoietic tissues of the embryonic brushtail possum (Trichosurus vulpecula)

Old

Deane

2003

Anat Embryol

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The lymphoid and immunohaematopoietic tissues of the embryonic and full-term brushtail possums was investigated histologically and immunohistochemically using antibodies to the T- and B-cell markers, CD3, CD5, CD79a and CD79b. No clearly defined thymus, bone marrow, spleen, lymph nodes, gut-associated lymphoid tissues or bronchus-associated lymphoid tissues were observed histologically. The liver was haematopoietic and contained erythrocytic and granulocytic precursors. No mature lymphocytes were observed histologically or detected using antibodies to T- and B-cell markers in any of the tissues. These results are consistent with other studies of the early postnatal tissues of other marsupials and support the proposition that neonatal marsupials are substantially reliant on maternal immunological protection at the time of birth and for a significant period of pouch life.

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The structure of the lung of the newborn marsupial bandicoot,Isoodon macrounus

Cited by 32 publications

References 17 publications

The appearance and distribution of mature T and B cells in the developing immune tissues of the stripe‐faced dunnart (Sminthopsis macroura)

The appearance and distribution of mature T and B cells in the developing immune tissues of the stripe‐faced dunnart (Sminthopsis macroura)

Organogenesis of the pituitary, adrenal, and lung at birth in the wallaby, Macropus rufogriseus

The lymphoid and immunohaematopoietic tissues of the embryonic brushtail possum (Trichosurus vulpecula)

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