The structure of the cytokine gene network in uterine fibroids

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

“…More studies using serology and biochemical characterization of past infections are needed to clarify the associations between RTIs and uterine fibroids. Interestingly, multiple associations between the higher occurrence of uterine fibroid inflammatory mediator gene polymorphisms, including interleukin (IL)-1β ( 347 , 348 ), IL-4 ( 349 ), TNF-α ( 349 , 350 ), IL-6 ( 351 ), IL-10 ( 348 ), and IL-12b receptor ( 352 ), have been reported.…”

Integrated bioinformatics analysis of the gene structure of polygenic diseases to develop effective methods for their early prognosis

“…The study was conducted using the SNP methods, various variants of data mining and machine learning (simulation modeling, MDR method, bioinformatic analysis of gene networks) [4,5]. Statistical processing of the results was carried out based on a methodological, including a comprehensive computer analysis of gene chains of various dimensions with an analysis of their structural and functional organization in terms of their possible pathogenetic role in the development of the particular polygenic disease [6]. This approach allowed us to identify highly informative gene ensembles associated with the development of each of the studied diseases.…”