The structure of the carbohydrate moiety of an acidic polysaccharide produced by Aureobasidium sp. K-1.

Hamada, Nobutake; Tsujisaka, Yoshio

doi:10.1271/bbb1961.47.1167

Cited by 15 publications

(6 citation statements)

References 1 publication

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“…Consequently, the viscosity of the culture solution increases to several thousand cP. AP is an imperfect fungus and typically grows in the mycelial form; however, it assumes a yeast-like form at the APβG production stage—the reason it has acquired the moniker “black yeast.” AP also produces black melanin in the late phase of culture, but ascorbic acid can be used to effectively suppress melanin production [ 18 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

Suzuki¹,

Kusano

Kondo

et al. 2021

Nutrients

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The black yeast Aureobasidium pullulans produces abundant soluble β-1,3-1,6-glucan—a functional food ingredient with known health benefits. For use as a food material, soluble β-1,3-1,6-glucan is produced via fermentation using sucrose as the carbon source. Various functionalities of β-1,3-1,6-glucan have been reported, including its immunomodulatory effect, particularly in the intestine. It also exhibits antitumor and antimetastatic effects, alleviates influenza and food allergies, and relieves stress. Moreover, it reduces the risk of lifestyle-related diseases by protecting the intestinal mucosa, reducing fat, lowering postprandial blood glucose, promoting bone health, and healing gastric ulcers. Furthermore, it induces heat shock protein 70. Clinical studies have reported the antiallergic and triglyceride-reducing effects of β-1,3-1,6-glucan, which are indicators of improvement in lifestyle-related diseases. The primary and higher-order structures of β-1,3-1,6-glucan have been elucidated. Specifically, it comprises a single highly-branched glucose residue with the β-1,6 bond (70% or more) on a backbone of glucose with 1,3-β bonds. β-Glucan shows a triple helical structure, and studies on its use as a drug delivery system have been actively conducted. β-Glucan in combination with anti-inflammatory substances or fullerenes can be used to target macrophages. Based on its health functionality, β-1,3-1,6-glucan is an interesting material as both food and medicine.

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Section: Resultsmentioning

confidence: 99%

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

Suzuki¹,

Kusano

Kondo

et al. 2021

Nutrients

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“…With respect to attachment: the biosynthesis of pullulan, an extracellular polymeric substance (EPS) adhesive, is described for at least four Aureobasidium species (Gostinčar et al 2014 ) and also the production of other EPS, such as β-glucan and acidic polysaccharides, by different Aureobasidium species is known (Leal-Serrano et al 1980 ; Hamada and Tsujisaka 1983 ; Yurlova and de Hoog 1997 ; Lotrakul et al 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Aureobasidium melanogenum: a native of dark biofinishes on oil treated wood

Nieuwenhuijzen

Houbraken

Meijer

et al. 2016

Antonie van Leeuwenhoek

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The genus Aureobasidium, which is known as a wood staining mould, has been detected on oil treated woods in the specific stain formation called biofinish. This biofinish is used to develop a new protective, self-healing and decorative biotreatment for wood. In order to understand and control biofinish formation on oil treated wood, the occurrence of different Aureobasidium species on various wood surfaces was studied. Phenotypic variability within Aureobasidium strains presented limitations of morphological identification of Aureobasidium species. PCR amplification and Sanger sequencing of ITS and RPB2 were used to identify the culturable Aureobasidium species composition in mould stained wood surfaces with and without a biofinish. The analysed isolates showed that several Aureobasidium species were present and that Aureobasidium melanogenum was predominantly detected, regardless of the presence of a biofinish and the type of substrate. A.melanogenum was detected on wood samples exposed in the Netherlands, Cameroon, South Africa, Australia and Norway. ITS-specific PCR amplification, cloning and sequencing of DNA extracted from biofinish samples confirmed results of the culturing based method: A. melanogenum is predominant within the Aureobasidium population of biofinishes on pine sapwood treated with raw linseed oil and the outdoor placement in the Netherlands.Electronic supplementary materialThe online version of this article (doi:10.1007/s10482-016-0668-7) contains supplementary material, which is available to authorized users.

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“…Preparation of LMW--glucan: The A. pullulans 1A1 strain was cultured in Czapek's medium supplemented with 0.3% sodium ascorbate and 3% sucrose [11,15]. The resulting culture was treated under alkaline conditions by the addition of NaOH (pH 13) to lower its viscosity.…”

Section: Methodsmentioning

confidence: 99%

Water-soluble low-molecular-weight b-(1, 3–1, 6) D-Glucan inhibit cedar pollinosis

Jippo

Suzuki

Sato

et al. 2015

FFHD

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Background: The incidences of allergenic diseases such as allergenic rhinitis, atopic dermatitis, asthma, and food allergies have increased in several countries. Mast cells have critical roles in various biological processes related to allergenic diseases. Mast cells express the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. Those mediators and cytokines proceed the allergenic diseases. We investigated the effects of water-soluble, low-molecular-weight b-(1, 3–1, 6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-b-glucan) on mast cell-mediated anaphylactic reactions. We reported that LMW-b-glucan dose-dependently inhibited the degranulation of mast cells. Furthermore, we found that orally administered LMW-b-glucan inhibited the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction in mice. Here, we examined if LMW-b-glucan had any effects on Japanese cedar pollinosis.Findings: In a clinical study, a randomized, single-blind, placebo-controlled, parallel group study in 65 subjects (aged 22-62) was performed. This study was undertaken 3 weeks before the cedar pollen season and until the end of the cedar pollen season. During the study, all subjects consumed one bottle of placebo or LMW-b-glucan daily, and all subjects were required to record allergenic symptoms in a diary. The LMW-b-glucan group had a significantly lower prevalence of sneezing, nose-blowing, tears, and hindrance to the activities of daily living than the placebo group.Conclusions: These results suggest that LMW-b-glucan could be an effective treatment for allergenic diseases.Key Words: Mast cell, anti-allergy, b-glucan, cedar pollinosis

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The structure of the carbohydrate moiety of an acidic polysaccharide produced by Aureobasidium sp. K-1.

Cited by 15 publications

References 1 publication

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

Aureobasidium melanogenum: a native of dark biofinishes on oil treated wood

Water-soluble low-molecular-weight b-(1, 3–1, 6) D-Glucan inhibit cedar pollinosis

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