The Structure of the Bladder Neck in Male Bladder Neck Obstruction

Abstract

A light microscope and neurohistochemical study is presented of full thickness biopsies from the bladder neck of 10 middle-aged males with urodynamically proven bladder neck obstruction. Apart from varying degrees of collagen deposition in seven cases, no abnormality was present in the detrusor and pre-prostatic components of the bladder neck muscles or in the distribution of cholinergic nerve fibres. The normal noradrenergic innervation to the pre-prostatic sphincter was absent in all specimens; this may be age-related.

Effects of Prazosin in Men with Symptoms of Bladder Neck Obstruction and a Non-Hyperplastic Prostate

“…The primary cause of the disorder is not known (5,9,24), Badenoch (5) reported 26 cases "to be congenital in origin". Relying on histological examination, he claimed that in his series, no patient was found to have fibrosis, but normal smooth muscle tissue around the bladder neck.…”

The Use of Sacral Reflex Latencies in Detrusor Bladder Neck Dyssynergia

“…al., 1973;Bates et al, 1975). Booth et al (1983) postulated that the cause could be an abnormality of the pre-prostatic sphincter, or of the sympathetic innervation to that area, but could not substantiate these claims by light microscopy or histochemistry, though it has been suggested that there is an increase in sympathetic nerves in the bladder neck in these cases. Turner-Warwick (1979) concluded that the muscle of the bladder neck itself was disordered, although no studies have been reported to ascertain whether a neuropathic element was involved.…”