2012
DOI: 10.1107/s0907444912026236
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The structure ofEnterococcus faecalisthymidylate synthase provides clues about folate bacterial metabolism

Abstract: Drug resistance to therapeutic antibiotics poses a challenge to the identification of novel targets and drugs for the treatment of infectious diseases. Infections caused by Enterococcus faecalis are a major health problem. Thymidylate synthase (TS) from E. faecalis is a potential target for antibacterial therapy. The X-ray crystallographic structure of E. faecalis thymidylate synthase (EfTS), which was obtained as a native binary complex composed of EfTS and 5-formyltetrahydrofolate (5-FTHF), has been determin… Show more

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Cited by 33 publications
(62 citation statements)
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References 51 publications
(61 reference statements)
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“…DNA base T) in the vast majority of organisms, including some bacteria and DNA viruses. 11-13 TSase is over-expressed in tumor cells to facilitate the faster DNA replication. 14,15 Consequently, TSase has been an attractive target for both antibiotic and anticancer drugs.…”
Section: Introductionmentioning
confidence: 99%
“…DNA base T) in the vast majority of organisms, including some bacteria and DNA viruses. 11-13 TSase is over-expressed in tumor cells to facilitate the faster DNA replication. 14,15 Consequently, TSase has been an attractive target for both antibiotic and anticancer drugs.…”
Section: Introductionmentioning
confidence: 99%
“…To combat this, clinical efforts have been focused on developing new potential antibiotics against bacteria that are resistant to those currently being used. Bacterial TS is indeed a promising target for the development of novel antibacterial compounds . To the best of our knowledge, there are only two chemical compounds reported as solo selective inhibitors of T. gondii TS .…”
Section: Introductionmentioning
confidence: 99%
“…In the last year, we determined for the first time the X‐ray crystallographic structure of E . faecalis thymidylate synthase, which should be an interesting target for antibacterials . This work takes origin from the series of 2‐amino‐1,3‐benzothiazoles ( 1a , 1b , 1c , 1d , 1e , 1f , 1g , 1h , Fig.…”
Section: Introductionmentioning
confidence: 99%