The structure of a tetrameric septin complex reveals a hydrophobic element essential for NC-interface integrity
Benjamin Grupp,
Lukas Denkhaus,
Stefan Gerhardt
et al.
Abstract:The septins of the yeast Saccharomyces cerevisiae assemble into hetero-octameric rods by alternating interactions between neighboring G-domains or N- and C-termini, respectively. These rods polymerize end to end into apolar filaments, forming a ring beneath the prospective new bud that expands during the cell cycle into an hourglass structure. The hourglass finally splits during cytokinesis into a double ring. Understanding these transitions as well as the plasticity of the higher order assemblies requires a d… Show more
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