The Structure and Uses of Genetically Homogeneous Lines of Animals

Kalter, Harold

doi:10.1007/978-1-4615-8939-6_6

Cited by 3 publications

(3 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the historical control, 30 fetuses with microphthalmia and one fetus with micrognathia had been recorded among 1,059 fetuses examined. Since these two sets of control data do not (Kalter, 1978). This was indeed the case in the present study.…”

Section: As Shown Insupporting

confidence: 69%

Frequency and Type of Malformations in the Offspring of C57BL/6 Male Mice Treated with Ethylnitrosourea

Nagao

Fujikawa

1996

Congenital Anomalies

View full text Add to dashboard Cite

Male mice of inbred strain C57BL/6 were intraperitoneally treated with ethylnitrosourea (ENU). On days 64-80 after the treatment, the males were mated with untreated virgin females of the same strain and allowed to utilize sperm that were spermatogonial stem cells at the time of treatment. On day 18 of gestation, viable fetuses were inspected for external malformations. The frequency of externally malformed fetuses in the ENU-treated series increased significantly over the control level. Malformations occurred spontaneously in the control series were microphthalmia and micrognathia. In the ENU-treated series as well, they occurred and no other malformations were encountered.The frequencies among total malformations of microphthalmia were 95% and 92% in the control and the ENU-treated series, respectively. Based on these results and other data, we propose that the male-mediated teratogenesis represents spontaneous teratogenesis that is enhanced over the normal level by paternally transmitted germ-line mutation(s).

show abstract

Section: As Shown Insupporting

confidence: 69%

Frequency and Type of Malformations in the Offspring of C57BL/6 Male Mice Treated with Ethylnitrosourea

Nagao

Fujikawa

1996

Congenital Anomalies

View full text Add to dashboard Cite

show abstract

“…This suggests that different cell lines or genotypes may play a role in the overall ability of the cells to differentiate to a desired lineage. Kalter [1979] suggested that the use of multiple inbred strains of mice would test a wide spectrum of the mouse genome and give a better idea of the variety of responses of which the species was capable. However, the use of multiple inbred strains of mice to test a single chemical greatly increases the expense of such an evaluation [Inselman et al 2011] and still does not address the issue of cross species extrapolation.…”

Section: Mouse Embryonic Stem Cell Test (Mest)mentioning

confidence: 99%

Alternative models in developmental toxicology

Lee¹,

Inselman²,

Kanungo

et al. 2012

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

“…These typically occur with some frequency in controls; their type and prevalence is strain-and species-specific. For a review of strain specificity, see Kalter (1978). For a recent compendium of historic control data in the Sprague-Dawley rat and NZW rabbit, see http://www.hcd.org/.…”

mentioning

confidence: 98%