“…On the grounds that detergent-protein complexes, as described in the necklace model, can be regarded as extended polymers, SDS-protein complexes, like nucleic acids, have been proposed (11) to migrate in a serpentine fashion designated as reptation (37,38), as suggested earlier (28). Since effective pore radii in polyacrylamide gels are typically around 3.0 nm, while the spacing between two neighboring micellar clusters in SDS-protein complexes was found to be Ͼ7.0 nm (34), the Ogston theory is not expected to be generally applicable (11).…”