The Structure and Connections of the Claustrum

Druga, R

doi:10.1016/b978-0-12-404566-8.00002-7

Cited by 39 publications

(52 citation statements)

References 165 publications

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“…Only in the cat, did both parts of the claustrum contain relatively low and proportional numbers of CR-expressing neurons (Rahman and Baizer 2007). Similarly to previous results presented in the mouse (Real et al 2003), rat (Druga 2014) and rabbit ) single CR-IR neurons found in the chinchilla's Cl were localized in the marginal zone of the insula. On the other hand in the cat (Rahman and Baizer 2007) and monkey (Reynhout and Baizer 1999), CR-expressing neurons were evenly scattered throughout Cl.…”

Section: Discussionsupporting

confidence: 66%

“…In the mouse Cl, CR-expressing neurons were evenly distributed throughout the nucleus (Real et al 2003), which closely resembles the pattern presented in this study in the chinchilla. However, in the rat CR-IR neurons detected both in Cl and EN were predominantly localized in close neighborhood to the insular cortex (Druga 2014). The topographical localization of CR-IR neurons in the EN of the rabbit is hard to determine because in this nucleus only incidental CR-positive neurons were found .…”

Section: Discussionmentioning

confidence: 87%

“…In general, the pattern presented above is in line with results obtained in most animal species studied, excluding the mouse and rat. In Cl of the latter animal species, CR-IR neurons were predominantly categorized as medium-sized multipolar, oval and fusiform in shape (Druga 2014, Real et al 2003. In the rat Cl and EN, the larger diameter of CR-IR neurons present in the rat Cl and EN is substantially larger when compared to the moderate parameters measured in the chinchilla (respectively 13.7 ± 0.3 μm and 8.4 ± 1.2 μm in Cl and 15.6 ± 0.3 μm and 11.0 ± 1.1 μm in EN).…”

Section: Discussionmentioning

confidence: 99%

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Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Szalak¹,

Matysek²,

Mozel³

et al. 2015

Polish Journal of Veterinary Sciences

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Calretinin (CR) as a buffer and sensor protein plays an important role in regulatory processes of Ca 2+ and anty-apoptotic cellular protection. In the present study, immunohistochemical peroxidase-antiperoxidase (PAP) method was used in order to determine the numbers, morphology, morphometry and distribution pattern of CR in neurons of the chinchilla's claustrum (Cl) and endopiriform nucleus (EN). In Cl and EN the presence of several classes of neurons with different immunoreactivity to CR was found. In Cl, CR-immunoreactive (IR) neurons were predominantly found in close vicinity to insular border while CR-IR neurons were evenly scattered throughout EN. In general, immunoreaction to CR was observed in neuronal cytoplasm, nucleus and in fibres-like nerve extensions. Statistical analysis showed the differences between average large diameter as well as cross-sectional area of CR-IR neurons present in Cl and EN. It is suggested, that CR acting as a calcium binding protein may play a role in neuronal network. Further co-localization studies are necessary to fully elucidate neurophysiology and neuropathology of the chinchilla's Cl and EN neurons.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Szalak¹,

Matysek²,

Mozel³

et al. 2015

Polish Journal of Veterinary Sciences

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“…This pattern is clearly apparent already in basal insectivores [Sanides, 1969;Dinopoulos et al, 1992;Künzle and Radtke-Schuller, 2001], and it was reviewed recently by Druga [2014]. In some mammals, such as cats and monkeys, the claustrum apparently has distinct visual, sensorimotor, and auditory sectors based on topographically organized connections with the corresponding parts of the cerebral cortex [Druga, 2014]. In rats, the topography of such partial connections is coarse, with marked overlaps [Druga, 2014].…”

Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

“…In some mammals, such as cats and monkeys, the claustrum apparently has distinct visual, sensorimotor, and auditory sectors based on topographically organized connections with the corresponding parts of the cerebral cortex [Druga, 2014]. In rats, the topography of such partial connections is coarse, with marked overlaps [Druga, 2014]. The insula receives afferents from some sensory thalamic nuclei (particularly pain, visceroceptive, and gustatory inputs), is reciprocally connected with the amygdala as well as with limbic and association cortical areas, and is implicated in widely different functions ranging from pain perception and speech production to the processing of social distaste emotions [Lundy and Norgren, 2004;Whitehead, 2012;Nieuwenhuys, 2012;Smythies et al, 2014].…”

Section: Connectivity Of the Claustro-insular Lpall With Thoughts Onmentioning

confidence: 99%

Comments on the Updated Tetrapartite Pallium Model in the Mouse and Chick, Featuring a Homologous Claustro-Insular Complex

Puelles

2017

Brain Behav Evol

142

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This essay reviews step by step the conceptual changes of the updated tetrapartite pallium model from its tripartite and early tetrapartite antecedents. The crucial observations in mouse material are explained first in the context of assumptions, tentative interpretations, and literature data. Errors and the solutions offered to resolve them are made explicit. Next, attention is centered on the lateral pallium sector of the updated model, whose definition is novel in incorporating a claustro-insular complex distinct from both olfactory centers (ventral pallium) and the isocortex (dorsal pallium). The general validity of the model is postulated at least for tetrapods. Genoarchitectonic studies performed to check the presence of a claustro-insular field homolog in the avian brain are reviewed next. These studies have indeed revealed the existence of such a complex in the avian mesopallium (though stratified outside-in rather than inside-out as in mammals), and there are indications that the same pattern may be found in reptiles as well. Peculiar pallio-pallial tangential migratory phenomena are apparently shared as well between mice and chicks. The issue of whether the avian mesopallium has connections that are similar to the known connections of the mammalian claustro-insular complex is considered next. Accrued data are consistent with similar connections for the avian insula homolog, but they are judged to be insufficient to reach definitive conclusions about the avian claustrum. An aside discusses that conserved connections are not a necessary feature of field-homologous neural centers. Finally, the present scenario on the evolution of the pallium of sauropsids and mammals is briefly visited, as highlighted by the updated tetrapartite model and present results.

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The Claustrum in the Squirrel Monkey

Baizer

Webster

Baker

2019

The Anatomical Record

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The claustrum (CLA) is a subcortical structure that is reciprocally and topographically connected with the cerebral cortex. The complexity of the cerebral cortex varies dramatically across mammals, raising the question of whether there might also be differences in CLA organization, circuitry, and function. Species variations in the shape of the CLA are well documented. Studies in multiple species have identified subsets of neurochemically distinct interneurons; some data suggest species variations in the nature, distribution, and numbers of different neurochemically identified neuronal types. We have studied the CLA in a smooth-brained primate, the squirrel monkey, using Nissl-stained sections and immunohistochemistry. We found that the shape of the CLA is different from that in other primates. We found several different neurochemically defined populations of neurons equally distributed throughout the CLA. Immunoreactivity to GAD 65/67 and GABA A receptors suggest that GABAergic interneurons provide widespread inhibitory input to CLA neurons. Immunoreactivity to glutamate transporters suggests widespread and overlapping excitatory input from cortical and possibly subcortical sources. Comparison of CLA organization in different species suggests that there may be major species differences both in the organization and in the functions of the CLA.

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The Structure and Connections of the Claustrum

Cited by 39 publications

References 165 publications

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Comments on the Updated Tetrapartite Pallium Model in the Mouse and Chick, Featuring a Homologous Claustro-Insular Complex

The Claustrum in the Squirrel Monkey

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