Abstract:The incorporation of heme into apo-forms of hemoproteins is an indispensable process for them to acquire biological functions. Heme oxygenase (HO) catalyzes the oxidative cleavage of protoheme to biliverdin utilizing dioxygens and reducing equivalents from cytochrome P450 reductase. HO is not a hemoprotein by nature, but once it binds heme, it behaves like a hemoprotein. Because apo-states of most hemeproteins are not native forms and unstable, HO (apoHO) could be a useful model to investigate the formation of… Show more
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