The Structural and Molecular Mechanisms of Mycobacterium tuberculosis Translational Elongation Factor Proteins
Ning Fang,
Lingyun Wu,
Shuyan Duan
et al.
Abstract:Targeting translation factor proteins holds promise for developing innovative anti-tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at messenger RNA (mRNA). To maintain protein homeostasis, bacteria have evolved various ribosome rescue mechanisms, including the predominant trans-translation process, to release stalled ribosomes and remove aberrant mRNAs. The rescue systems require the participation of translation elongation factor proteins (EFs) and are essential for bacter… Show more
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