The strongin vitroandvivocytotoxicity of three new cobalt(ii) complexes with 8-methoxyquinoline

Abstract

Three new cobalt(II) complexes, [Co(MQL)2Cl2] (CoCl), [Co(MQL)2Br2] (CoBr), and [Co(MQL)2I2] (CoI), bearing 8-methoxyquinoline (MQL) have been first designed. MTT showed that, CoCl, CoBr, and CoI exhibited much better antiproliferative activity...

Synthesis and anticancer mechanisms of four novel platinum(ii) 4′-substituted-2,2′:6′,2′′-terpyridine complexes

“…When the ovarian SKO3 tumor volume was approximately 0.10 cm 3 , tpy1Pt was intraperitoneally injected into the model mice. 47–50 Notably, tpy1Pt exhibited a strong inhibition rate (52.4%, p value < 0.05) after 21 days of treatment. Moreover, no deaths or significant body changes were recorded in the tpy1Pt -treated group, indicating the safety of tpy1Pt (Fig.…”

“…It was difficult to determine whether metal anticancer drugs induce cancer cell necrosis or apoptosis using MTT or CCK-8 assays. 47,48 Therefore, double staining using annexin V-FITC and propidium iodide was performed to assess whether treatment of SKO3cisR cancer cells with tpy1Pt (0.23 μM) and tpy2Pt (1.97 μM) causes cell apoptosis or death. As shown in Fig.…”