The ?strip? patch test: results of a multicentre study towards a standardization

Dickel, Heinrich; Brückner, Thomas; Erdmann, Stephan; Fluhr, Joachim W.; Frosch, Peter J.; Grabbe, Jürgen; Löffler, Harald; Merk, Hans F.; Pirker, Claudia; Schwanitz, Hans Joachim; Weißhaar, Elke; Brasch, Jochen

doi:10.1007/s00403-004-0496-x

Cited by 44 publications

(77 citation statements)

References 36 publications

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“…In the present study, our proposed SPT protocol [11] proved to be reproducible with respect to different patients or users. In daily clinical routine, we can therefore V alues in parentheses denote min-max, Q1 and Q3, unless specified otherwise.…”

Section: Discussionmentioning

confidence: 92%

“…We defined a length of 20% points for this 4 -interval as indicating clinical similarity of SC reduction across subjects, i.e. good reproducibility of our proposed protocol for performing the SPT [11] . As is the central parameter for this 4 -interval, we planned this study based on a 95% CI for .…”

Section: Discussionmentioning

confidence: 99%

“…Three test areas were randomly marked as A, B and G receiving the following treatments: B = no tape strips (baseline value of SC thickness measurement); G = strips down to the stratum lucidum (SL; reference value for calculating tape strips for the SPT), and A = calculated tape strips for the SPT (formula: tape strips down to the SL ! 11/26 [11] ; target value of SC thickness measurement). Randomization of test side and test areas was conducted according to a randomization list in the total of 75 subjects (supervised by O.K.).…”

Section: Tape Strippingmentioning

confidence: 99%

“…Tape stripping was performed according to our formerly proposed protocol for performing the SPT [11] . It was carried out with a 3M Blenderm surgical tape (3M Medica, 3M Deutschland GmbH, Neuss, Germany; 25 mm !…”

Section: Tape Strippingmentioning

confidence: 99%

“…We proposed a first standardized protocol for uniformly performing the SPT [11] and subsequently proved a significant increase in test sensitivity of the SPT versus…”

Section: Introductionmentioning

confidence: 99%

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Standardized Tape Stripping: A Practical and Reproducible Protocol to Uniformly Reduce the Stratum Corneum

Dickel

Goulioumis

Gambichler

et al. 2010

Skin Pharmacol Physiol

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The basic idea of the strip patch test (SPT), a modification of the conventional patch test (PT), is to increase the bioavailability of a test substance in the deeper epidermal cell layers by defined tape stripping of the test area on the back prior to a PT. In a prospective, investigator-blinded clinical study, we evaluated the variability and the interrater agreement of our proposed SPT protocol. The relative stratum corneum (SC) reduction after tape stripping was measured on 75 subjects for variability and in a subgroup of 18 subjects for interrater agreement, by performing in vivo confocal laser scanning microscopy. We found good reproducibility with an SC reduction of 31%, with 95% of the values lying between 22 and 40%, and good interrater agreement. As a result, our SPT protocol yields a clinically adequate standardization of the SC reduction and the SPT may therefore be recommended for performance in daily clinical routine.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Tape Strippingmentioning

confidence: 99%

Section: Tape Strippingmentioning

confidence: 99%

“…We proposed a first standardized protocol for uniformly performing the SPT [11] and subsequently proved a significant increase in test sensitivity of the SPT versus…”

Section: Introductionmentioning

confidence: 99%

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