SUMMARYObservational (nonexperimental) studies of the association of infant feeding and subsequent child or adult behavior are prone to residual confounding by subtle differences in psychological attributes and interactional styles of mothers who breastfeed vs those who formula-feed. We followed up 13,889 6.5-year-old Belarusian children who participated in a large clusterrandomized trial of a breastfeeding promotion intervention. Behavior was evaluated using the Strengths and Difficulties Questionnaire (SDQ), completed independently by the children's parents and teachers. We compared the results of experimental (intention-to-treat, ITT) and observational analyses (based on feeding actually received), both adjusted for clustering. Observational analyses were additionally adjusted for geographic region and urban vs rural residence; child sex, age at follow-up, and birth weight; and maternal and paternal education. No differences between the randomized experimental vs control groups were observed in ITT analyses. In contrast, small but statistically significant associations with weaning prior to 3 months were observed for parent and teacher SDQ scores on total difficulties, conduct problems, and hyperactivity, even after multivariate adjustment. The absence of associations based on ITT analyses, in contrast with the significant associations based on observed BF duration, strongly suggests that the latter are biased by residual confounding.