The strength of adhesive-bonded tissue joints

Chivers, Robin A.; Wolowacz, R.G.

doi:10.1016/s0143-7496(96)00041-3

Cited by 68 publications

(46 citation statements)

References 16 publications

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“…However, only a few investigators have studied the use of this exotic adhesive for surgical applications. Benedict and Picciano [38], Schnurrer and Lehr [39], and Chivers and Wolowacz [40] reported that the mussel adhesive formed weak bonds. These investigators used distinctly different curing conditions and joint configurations, which makes direct comparison cumbersome.…”

Section: Introductionmentioning

confidence: 99%

Adhesive strength and curing rate of marine mussel protein extracts on porcine small intestinal submucosa

et al. 2007

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An adhesive protein extracted from marine mussel (Mytilus edulis) was used to bond strips of connective tissue for the purpose of evaluating the use of curing agents to improve adhesive curing. Specifically, mussel adhesive protein solution (MAPS, 0.5 mM dihydroxyphenylalanine) was applied, with or without the curing agents, to the ends of two overlapping strips of porcine small intestinal submucosa. The bond strength of this lap joint was determined after curing for 1 h at room temperature (25°C). The strength of joints formed using only MAPS or with only the ethyl, butyl or octyl cyanoacrylate adhesives were determined. Although joints bonded using ethyl cyanoacrylate were strongest, those using MAPS were stronger than those using butyl and octyl cyanoacrylates. The addition of 25 mM solutions of the transition metal ions V 5+ , Fe 3+ and Cr 6+ , which are all oxidants, increased the bond strength of the MAPS joints. The V 5+ gave the strongest bonds and the Fe 3+ the second strongest. In subsequent tests with V 5+ and Fe 3+ solutions, the bond strength increased with V 5+ concentration, but it did not increase with Fe 3+ concentration. Addition of 250 mM V 5+ gave a very strong bond.

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Section: Introductionmentioning

confidence: 99%

Adhesive strength and curing rate of marine mussel protein extracts on porcine small intestinal submucosa

et al. 2007

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“…The strength of the adhesive was highly dependent on the test substrate. As shown in Table 6, cyanoacrylate displayed the greatest adhesive strength over gelatin-based adhesive and fibrin [38]. and blood [10,11].…”

Section: Tensile Strengthmentioning

confidence: 94%

“…The results from the test showed that the increase of silver nanoparticle concentration yields a slight decrease in adhesive force. Chivers et al evaluated the adhesive properties of several common tissue adhesives, such as cyanoacrylate, gelatin-based adhesive, and fibrin [38]. They tested the adhesive strength of the adhesive to porcine skin, bone, and cartilage.…”

Section: Tensile Strengthmentioning

confidence: 99%

“…Adhesive was applied in between overlapping skin and then allowed to cure. This specimen was then clamped by the grips of the universal testing machine and pulled at 5 mm/min until the bond completely failed [38]. The strength of the adhesive was highly dependent on the test substrate.…”

Section: Tensile Strengthmentioning

confidence: 99%

“…This is particularly important because the adhesive will prevent the two ends of tissue from further separation when sudden or excessive force is applied. Although doping the adhesive with silver nanoparticles increased the mechanical strength when tested on the porcine eyes, the strength of the adhesive on different tissues in the body can possibly vary because adhesive strength is highly dependent on the test substrate [38]. Since 2-octyl cyanoacrylate is already used to treat wounds from many areas of the body including the eye, the increased adhesive strength of the composite adhesive enhances the performance of the adhesive while imparting an antibacterial effect.…”

Section: Adhesive Force Testing On Porcine Eyesmentioning

confidence: 99%

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Characterization of silver nanoparticle-infused tissue adhesive for ophthalmic use

Yee

Selvaduray

Hawkins

2016

Journal of the Mechanical Behavior of Biomedical Materials

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This research examined if the infusion of silver nanoparticles into a 2-octyl cyanoacrylate tissue adhesive alters the antibacterial effectiveness and mechanical properties of the adhesive. Silver nanoparticle size and concentration combinations were varied to determine the effects of these factors. Uniform distribution of the silver nanoparticles was achieved before proceeding to testing. Antibacterial effectiveness of the composite adhesive was determined via the Kirby-Bauer disk diffusion susceptibility test and by CFU counting. Doping the adhesive with silver nanoparticles resulted in an order of magnitude reduction in bacterial growth. The greatest antibacterial effect came from imbuing 10 μg/mL of 4 nm silver nanoparticles into the tissue adhesive. Despite the noticeable reduction of bacterial growth for the doped adhesives, the difference among the varying silver nanoparticle size and concentration combinations was minimal.The breaking strength of the adhesive increased when silver nanoparticles were added. The adhesive strength of the composite adhesive attached to an incised porcine sclera was also greater than the unaltered adhesive. The greatest breaking load and adhesive force was the 10 μg/mL of 10 nm silver nanoparticle-doped adhesive. The

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