The stratigraphical organisation of the microvascular systems of the porcine vocal folds

Reinhard, H. J.; Lang, Anja; Gasse, H.

doi:10.5603/fm.2014.0066

Cited by 1 publication

(1 citation statement)

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“…Despite the presence of extensive capillary and lymphatic networks in the vocal folds, resident immune cell populations were scarcely documented at the glottic region in vocally healthy adults. [31][32][33][34] Two remote studies may, however, provide some insights on this subject matter. A human fetus study showed that tissue-resident DCs, T-lymphocytes, and B-lymphocytes were observed in the mucosae covering subglottic and supraglottic regions but not of the glottic region.…”

Section: Immunological Profile Of the Vocal Foldsmentioning

confidence: 99%

Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective

Coburn

et al. 2021

Advanced NanoBiomed Research

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The vocal folds are functional organs located in the larynx that play a critical role in our daily breathing, speech, and swallowing functions. A key structural feature of the vocal folds is their delicate mucosa, which consists of a thin, layered epithelium and underlying extracellular matrix (ECM)-rich lamina propria. [1,2] Irreversible changes to the vocal fold mucosa, such as scarring, atrophy, and sulcus vocalis, require regenerative technologies to stimulate a controlled regrowth of the tissue. An increasing number of biomaterial systems have been proposed with the concurrent capability of refilling and regenerating severely damaged or absent vocal fold mucosae in situ (see review on public health significance in the study by Green et al. [3] ).Notably, as the vocal folds are located at the narrowest point of the airway, adverse hostÀbiomaterial responses can impair upper airway patency and create life-threatening complications. For instance, 2À5% of patients were reported to have postoperative inflammatory reactions including edema, dysphonia, and dyspnea to injectable biomaterials derived from hyaluronic acid (HA). [4][5][6] Although the incidence is rare, severe airway reactions could lead to an emergency admission for intensive care and require intubation procedures for breathing support. [5,7] Inevitably, this immunemediated rejection response is detrimental to the longevity, performance, and integration of the biomaterial in the vocal fold mucosa.Upon biomaterial introduction into a host, the immune system quickly responds to the iatrogenic trauma and foreign

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Section: Immunological Profile Of the Vocal Foldsmentioning

confidence: 99%