2020
DOI: 10.1016/j.pharmthera.2020.107686
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The strategies and techniques of drug discovery from natural products

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Cited by 144 publications
(85 citation statements)
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“…The high structural and physicochemical diversity of natural products makes them a valuable source to discover and develop new bioactive compounds with different pharmaceutical, cosmetic, biotechnological, agrochemical, and food applications (Rayan et al, 2017 ). Success histories of natural product-based drugs have been reported in the pharmaceutical industry and include pilocarpine, quinine, morphine, and artemisinin (Newman and Cragg, 2016 ; Zhang L. et al, 2020 ). Natural products represent relevant importance in the discovery and development of new bioinspired bioactive compounds, and more than 50% of the developed drugs approved by the United States Food and Drug Administration (USFDA, 1981–2019) are derived or bioinspired from compounds obtained from natural sources (Newman and Cragg, 2020 ).…”
Section: Natural Products As Sources Of Novel Bioactive Compounds and The Paradigms Of Their Explorationmentioning
confidence: 99%
See 1 more Smart Citation
“…The high structural and physicochemical diversity of natural products makes them a valuable source to discover and develop new bioactive compounds with different pharmaceutical, cosmetic, biotechnological, agrochemical, and food applications (Rayan et al, 2017 ). Success histories of natural product-based drugs have been reported in the pharmaceutical industry and include pilocarpine, quinine, morphine, and artemisinin (Newman and Cragg, 2016 ; Zhang L. et al, 2020 ). Natural products represent relevant importance in the discovery and development of new bioinspired bioactive compounds, and more than 50% of the developed drugs approved by the United States Food and Drug Administration (USFDA, 1981–2019) are derived or bioinspired from compounds obtained from natural sources (Newman and Cragg, 2020 ).…”
Section: Natural Products As Sources Of Novel Bioactive Compounds and The Paradigms Of Their Explorationmentioning
confidence: 99%
“…The systematic search for natural sources to obtain valuable compounds to develop products with commercial value and industrial purposes remains the most challenging task in bioprospecting (Skirycz et al, 2016 ; Roumpeka et al, 2017 ; Cubillos et al, 2019 ). The traditional approach to discover new bioactive compounds from natural sources includes sequential steps that are obtained from the biological material using ethnological knowledge, extraction, fractionation/isolation, chemical characterization, and, finally, the execution of the biological assays of the isolated or fractionated natural products (Zhang L. et al, 2020 ). Subsequent analyses include the lead compound optimization using chemical synthesis to perform structural modifications in order to improve their pharmacodynamic and pharmacokinetic properties and to increase their biological activities (Huffman and Shenvi, 2019 ).…”
Section: Natural Products As Sources Of Novel Bioactive Compounds and The Paradigms Of Their Explorationmentioning
confidence: 99%
“…Natural products have been used in traditional medicine for a long time, and since the appearance of modern science, they have been recognized as valuable sources of new drugs [ 1 , 2 , 3 , 4 , 5 ]. Considerable money has been invested in their isolation from natural sources and characterization of their structures and biological activities.…”
Section: Introductionmentioning
confidence: 99%
“…The alkaloid pilocarpine (5) can also be cited, obtained from leaves of Pilocarpus trees, Rutaceae (jaborandi), formerly used to treat glaucoma and currently employed to relieve xerostomia (Skirycz et al 2016). Another example is tubocurarine chloride or d-tubocurarine (6), a constituent of the curare, a traditional preparation made with Chondrodendron tomentosum Ruiz & Pav., Menispermaceae, introduced in anesthesiology in the 1940s due to its relaxing effect of skeletal musculature (Zhang et al 2020).…”
Section: Introductionmentioning
confidence: 99%