The Strategic National Stockpile: identification, support, and acquisition of medical countermeasures for CBRN incidents

Neumeister, Shondra; Gray, Joshua P.

doi:10.1080/15376516.2020.1853294

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…The SNS will then work to deliver the MCMs needed to the region’s central depot(s) within 12 h of notification. The length of time it takes for the SNS to deliver the MCMs to the regional depot is also dynamic and is dependent on the undisclosed location/s of SNS’ warehouses and the risk assessment of such an event in that public health region ( Center for Disease Control, 2014 ; Neumeister & Gray, 2021 ). Therefore, in order to utilize the time available effectively, it is potentially necessary to reroute with a decreased or increased time constraint dependent on the time remaining.…”

Section: Introductionmentioning

confidence: 99%

Benchmarking a fast, satisficing vehicle routing algorithm for public health emergency planning and response: “Good Enough for Jazz”

McDaniel,

Akwafuo,

Urbanovsky

et al. 2023

PeerJ Computer Science

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Due to situational fluidity and intrinsic uncertainty of emergency response, there needs to be a fast vehicle routing algorithm that meets the constraints of the situation, thus the receiving-staging-storing-distributing (RSSD) algorithm was developed. Benchmarking the quality of this satisficing algorithm is important to understand the consequences of not engaging with the NP-Hard task of vehicle routing problem. This benchmarking will inform whether the RSSD algorithm is producing acceptable and consistent solutions to be used in decision support systems for emergency response planning. We devise metrics in the domain space of emergency planning, response, and medical countermeasure dispensing in order to assess the quality of RSSD solutions. We conduct experiments and perform statistical analyses to assess the quality of the RSSD algorithm’s solutions compared to the best known solutions for selected capacitated vehicle routing problem (CVRP) benchmark instances. The results of these experiments indicate that even though the RSSD algorithm does not engage with finding the optimal route solutions, it behaves in a consistent manner to the best known solutions across a range of instances and attributes.

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Section: Introductionmentioning

confidence: 99%

Benchmarking a fast, satisficing vehicle routing algorithm for public health emergency planning and response: “Good Enough for Jazz”

McDaniel,

Akwafuo,

Urbanovsky

et al. 2023

PeerJ Computer Science

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Repurposing FDA‐approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees

Aleksunes,

Gray,

Meshanni

et al. 2024

Pharmacology Res & Perspec

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The risk of a terrorist attack in the United States has created challenges on how to effectively treat toxicities that result from exposure to chemical weapons. To address this concern, the United States has organized a trans‐agency initiative across academia, government, and industry to identify drugs to treat tissue injury resulting from exposure to chemical threat agents. We sought to develop and evaluate an interactive educational session that provides hands‐on instruction on how to repurpose FDA‐approved drugs as therapeutics to treat toxicity from exposure to chemical weapons. As part of the Rutgers Summer Undergraduate Research Fellowship program, 23 undergraduate students participated in a 2‐h session that included: (1) an overview of chemical weapon toxicities, (2) a primer on pharmacology principles, and (3) an interactive session where groups of students were provided lists of FDA‐approved drugs to evaluate potential mechanisms of action and suitability as countermeasures for four chemical weapon case scenarios. The interactive session culminated in a competition for the best grant “sales pitch.” From this interactive training, students improved their understanding of (1) the ability of chemical weapons to cause long‐term toxicities, (2) impact of route of administration and exposure scenario on drug efficacy, and (3) re‐purposing FDA‐approved drugs to treat disease from chemical weapon exposure. These findings demonstrated that an interactive training exercise can provide students with new insights into drug development for chemical threat agent toxicities.

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Modeling of Ca12O12, Mg12O12, and Al12N12 nanostructured materials as sensors for phosgene (Cl2CO)

Louis

Amodu

Unimuke

et al. 2022

Materials Today Communications

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The Strategic National Stockpile: identification, support, and acquisition of medical countermeasures for CBRN incidents

Cited by 4 publications

References 20 publications

Benchmarking a fast, satisficing vehicle routing algorithm for public health emergency planning and response: “Good Enough for Jazz”

Benchmarking a fast, satisficing vehicle routing algorithm for public health emergency planning and response: “Good Enough for Jazz”

Repurposing FDA‐approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees

Modeling of Ca12O12, Mg12O12, and Al12N12 nanostructured materials as sensors for phosgene (Cl2CO)

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