“…While antibodies to gangliosides inhibit nerve regeneration (Sparrow et al, 1984) ganglioside administration in vivo has been reported to facilitate nerve regeneration and functional recovery of the PNS following injury (Ceccarelli et al, 1976;Gorio et al, 1980Gorio et al, , 1983Sparrow and Graftstein, 1982;Robb and Keynes, 1984). Furthermore, the administration of gangliosides, in particular monosialoganglioside GM 1 (nomenclature according to Svennerholm, 1963) has been reported to ameliorate the outcome following injury to the CNS (Wojcik et al, 1982;Agnati et al, 1983;Karpiak, 1983;Toffano et al, 1983Toffano et al, , 1984Carmignoto et al, 1984;Fass and Ramirez, 1984;Jonsson et al, 1984;Oderfeld-Nowak et al, 1984;Sabel et al, 1984Sabel et al, , 1985Casamenti et al, 1985;Fujito et al, 1985;Commissiong and Toffano, 1986;Cue110 et al, 1986;Fusco et al, 1986;Gradkowska et al, 1986;Sofroniew et al, 1986).…”