The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions

Wójcik, Magdalena; Ułas, J.; Oderfeld-Nowak, B

doi:10.1016/0306-4522(82)90282-2

Cited by 139 publications

(42 citation statements)

References 13 publications

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“…This suggests that GM1 may not have the protective effect against ischemic neuronal damage that has been described for damaged peripheral nerves 40 or hippocampal lesions. 10 It should be noted, however, that the recovery process may not have been followed for a sufficient period of time and that single dose treatment may not have the optimal effect. The beneficial effect of GM1 on hippocampal damage as well as the axonal sprouting effect was found after longlasting treatment with repeated doses.…”

Section: Discussionmentioning

confidence: 99%

“…Since gangliosides are known to facilitate the recovery of the lesioned central nervous system over a period of 2 weeks or more, 10 ' 12 the effect of GM1 treatment should also be examined with a chronic stroke model.…”

Section: Discussionmentioning

confidence: 99%

“…The beneficial effect of GM1 on hippocampal damage as well as the axonal sprouting effect was found after longlasting treatment with repeated doses. 10 ' 4(W2 Only two treatment times were chosen as part of this ivnestigation -30 min and 120 min after the MCA occlusion; these may not have been the optimal times.…”

Section: Discussionmentioning

confidence: 99%

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Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats.

Tanaka¹,

Dóra²,

Urbanics

et al. 1986

Stroke

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SUMMARY The effect of the ganglioside GM1 on the recovery of local cerebral glucose metabolism QCMRgl), recovery kinetics of cerebrocortical electrical activity, cerebral blood flow and redox state as well as histological changes following focal ischemia has been studied in the cat. Ischemia was produced by occlusion of the left middle cerebral artery (MCA), and GM1 (30 mg/kg) was injected intravenously at 30 min after the MCA occluson or at the time of release of the occlusion, at 120 min. Another group of animals were subjected to the same ischemic insult, but without GM1 treatment, and sham-operated treated and not treated cats were also studied. The animals of both GM1-treated and non-treated stroke groups were classified into 2 groups (severe and moderate) depending on the depression of electrocortical activity in the ischemic hemisphere at 30 min of the ischemia. There was a significant increase in local cerebral blood flow in the ischemic area in the treated animals. Additionally there was a significant treatment effect on the left peripheral MCA territory for ICMRgl in the 30 min treated moderate group, (p < .05). This group of animals showed decreased ICMRgl accompanied by less severe histological damage suggesting that GM1 may produce metabolic depression so as to maintain a normal flow-metabolism couple and prevent ischemic structural damage. The possible mechanism of metabolic depression induced by GM1 is briefly discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats.

Tanaka¹,

Dóra²,

Urbanics

et al. 1986

Stroke

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show abstract

“…While antibodies to gangliosides inhibit nerve regeneration (Sparrow et al, 1984) ganglioside administration in vivo has been reported to facilitate nerve regeneration and functional recovery of the PNS following injury (Ceccarelli et al, 1976;Gorio et al, 1980Gorio et al, , 1983Sparrow and Graftstein, 1982;Robb and Keynes, 1984). Furthermore, the administration of gangliosides, in particular monosialoganglioside GM 1 (nomenclature according to Svennerholm, 1963) has been reported to ameliorate the outcome following injury to the CNS (Wojcik et al, 1982;Agnati et al, 1983;Karpiak, 1983;Toffano et al, 1983Toffano et al, , 1984Carmignoto et al, 1984;Fass and Ramirez, 1984;Jonsson et al, 1984;Oderfeld-Nowak et al, 1984;Sabel et al, 1984Sabel et al, , 1985Casamenti et al, 1985;Fujito et al, 1985;Commissiong and Toffano, 1986;Cue110 et al, 1986;Fusco et al, 1986;Gradkowska et al, 1986;Sofroniew et al, 1986).…”

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confidence: 99%

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: II. Modulatory effects of gangliosides

et al. 1988

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This paper analyzes the effects of exogenously supplied GM1 on the development, i.e., specific neurotransmitter uptake capability and survival, of the dopaminergic neurons present in fetal mouse- dissociated mesencephalic cells. Exogenous GM1, but not asialo-GM1, sialic acid, or the oligosaccharide chain of GM1, enhances in a time- and concentration-dependent manner the specific 3H-dopamine uptake (increase of the apparent Vmax and decrease of the apparent Km value) and the long-term survival of the dopaminergic neurons. The GM1 effects on the behavior of the dopaminergic neurons require the presence of cell-derived neuronotrophic influences present within the culture system and are associated with an increase in the response of the cells to the trophic influences. GM1 effects are not limited to dopaminergic neurons, and depend on the stable association of the ganglioside molecule with the cells. It is suggested that GM1 is not a trophic agent per se, but rather potentiates neuronotrophic activities and/or exerts independent influences to which neurons respond only if appropriately supported.

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“…Antibodies against GM1 have been detected consequently rather in motor than in sensory neuropathies. Antibodies against ganglioside GM1 are reported in patients with severe axonal destruction, such as in the case of Guillain-Barrè Syndrome (GBS) [10,34,35], the Multifocal Motor Neuropathy (MMN) [36] as well as in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and Amyotrophic Lateral Sclerosis (ALS) [37,38].…”

Section: Introductionmentioning

confidence: 99%

High Levels of Anti-Ganglioside Antibodies in Patients with Parkinson?s Disease Associated with Cognitive Decline

M¹

2015

Int J Neurorehabilitation Eng

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The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions

Cited by 139 publications

References 13 publications

Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats.

Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats.

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: II. Modulatory effects of gangliosides

High Levels of Anti-Ganglioside Antibodies in Patients with Parkinson?s Disease Associated with Cognitive Decline

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