The sticky relationship between allergies and infections

Wang, Jiu-Yao

doi:10.5415/apallergy.2015.5.3.133

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, PMM2-CDG patients displayed a greater tendency to attribute to age a positive effect on allergies (51.2%, n = 21/41) than controls (43.7%, n = 69/158) ( Figure S5B ). Studies have shown an interplay between allergies and infections [ 44 , 45 ]. Additionally, PMM2-CDG patients (29.3%, n = 24/82) showed a higher relative prevalence of concomitant allergies and infections when compared to the control (15.9%, n = 29/182) ( Figure 4 E).…”

Section: Resultsmentioning

confidence: 99%

New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach

Francisco

Pascoal

Marques‐da‐Silva

et al. 2020

JCM

View full text Add to dashboard Cite

Congenital disorders of glycosylation (CDG) are rare diseases with variable phenotypes and severity. Immunological involvement remains a largely uncharted topic in CDG, mainly due to lack of robust data. To better characterize immune-related manifestations’ prevalence, relevance, and quality-of-life (QoL) impact, we developed electronic questionnaires targeting (1) CDG patients and (2) the general “healthy” population. Two-hundred and nine CDG patients/caregivers and 349 healthy participants were included in this study. PMM2-CDG was the most represented CDG (n = 122/209). About half of these participants (n = 65/122) described relevant infections with a noteworthy prevalence of those affecting the gastrointestinal tract (GI) (63.1%, n = 41/65). Infection burden and QoL impact were shown as infections correlated with more severe clinical phenotypes and with a set of relevant non-immune PMM2-CDG signs. Autoimmune diseases had only a marginal presence in PMM2-CDG (2.5%, n = 3/122), all being GI-related. Allergy prevalence was also low in PMM2-CDG (33%, n = 41/122) except for food allergies (26.8%, n = 11/41, of PMM2-CDG and 10.8%, n = 17/158, of controls). High vaccination compliance with greater perceived ineffectiveness (28.3%, n = 17/60) and more severe adverse reactions were described in PMM2-CDG. This people-centric approach not only confirmed literature findings, but created new insights into immunological involvement in CDG, namely by highlighting the possible link between the immune and GI systems in PMM2-CDG. Finally, our results emphasized the importance of patient/caregiver knowledge and raised several red flags about immunological management.

show abstract

Section: Resultsmentioning

confidence: 99%

New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach

Francisco

Pascoal

Marques‐da‐Silva

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Moreover, other studies have reported that respiratory infections (i.e., viral infections) promote allergic sensitization and asthma in animal models [32,33]. In addition, Holt et al provided evidence that viral infections in early life trigger the development of asthma [34]. This has recently been proven by the findings of the critical role of IL-25 and IL-33 after rhinovirus infections and the development of asthma.…”

Section: Introductionmentioning

confidence: 99%

“…A new term, “The viral march”, was even proposed to describe the connection between early life virus wheezing and subsequent asthma. Furthermore, the treatment of allergic diseases, such as the use of allergen-specific immunotherapy, can reduce the incidence of respiratory infections [34].…”

Section: Introductionmentioning

confidence: 99%

Association of Breastfeeding Duration with Susceptibility to Allergy, Influenza, and Methylation Status of TLR1 Gene

et al. 2019

View full text Add to dashboard Cite

Background and Objectives: This study aimed to investigate the possible association between exclusive breastfeeding duration during early infancy and susceptibility to allergy and influenza in adulthood. Furthermore, we also investigated the association of breastfeeding duration with DNA methylation at two sites in the promoter of the toll-like receptor-1 (TLR1) gene, as well as the association between DNA methylation of the toll-like receptor-1 (TLR1) gene and susceptibility to different diseases. Materials and Methods: Blood samples were collected from 100 adults and classified into two groups according to breastfeeding duration (<6 months and ≥6 months) during infancy. Subjects were asked to complete a questionnaire on their susceptibilities to different diseases and sign a consent form separately. Fifty-three samples underwent DNA extraction, and the DNA samples were divided into two aliquots, one of which was treated with bisulfite reagent. The promoter region of the TLR1 gene was then amplified by polymerase chain reaction (PCR) and sequenced. Results: We found a significant association between increased breastfeeding duration and a reduction in susceptibility to influenza and allergy, as well asa significant reduction in DNA methylation within the promoter of the TLR1 gene. No association was found between DNA methylation and susceptibility to different diseases. Conclusions: The findings demonstrate the significance of increased breastfeeding duration for improved health outcomes at the gene level.

show abstract

Allergies, infections, and psychiatric disorders among Black Americans: findings from the National Survey of American Life

Stickley

Lincoln

et al. 2019

Ethnicity & Health

View full text Add to dashboard Cite

The sticky relationship between allergies and infections

Cited by 5 publications

References 17 publications

New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach

New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach

Association of Breastfeeding Duration with Susceptibility to Allergy, Influenza, and Methylation Status of TLR1 Gene

Allergies, infections, and psychiatric disorders among Black Americans: findings from the National Survey of American Life

Contact Info

Product

Resources

About