The stem cell code in oral epithelial tumorigenesis: ‘The cancer stem cell shift hypothesis’

Richard, Vinitha; Pillai, M. Radhakrishna

doi:10.1016/j.bbcan.2010.06.004

Cited by 34 publications

(56 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epidermal growth factor receptor, EGFR, which is also known as ErbB1 or HER1, is duly found to be upregulated in cancers which is involved in a wide range of biological processes such as cell proliferation, cell survival, cell differentiation and cell migration followed by invasion [34]. Oral cancer hence can be targeted by drugs such as cetuximab [33,35].…”

Section: Relevance Of Other Markers For Hnscc Carcinogenesismentioning

confidence: 99%

Role of MTA1 in head and neck cancers

Marzook

Deivendran

Kumar

et al. 2014

Cancer Metastasis Rev

Self Cite

View full text Add to dashboard Cite

Head and neck cancers usually originate in the squamous cells that line the inner mucosal surfaces of the oral and the neck region. These cancers follow multifocal steps for progression that include risk of developing metastasis. Although therapeutics has advanced in the past decades, head and neck cancers continue to cause much morbidity and mortality. Even with the promising effect of targeted therapies, there is a need for a better evaluation of patients with head and neck cancers. Metastasis-associated tumour antigen 1 (MTA1), a chromatin modifier, is found as an integral part of nucleosome remodelling and histone deacetylation (NuRD) complex. MTA1 is a biomarker for several solid tumours, and the overexpression of which have been documented in various cancers such as breast, ovarian, colon, prostrate etc. Interestingly also, a set of head and neck cancers shows MTA1 overexpression. However, recent evidences from clinical data raise a critical question on the role of MTA1 in head and neck cancers. This calls for a detailed review to the role of MTA1 in oral cancer. This review gives a brief account on the existing biological and molecular data in the context of head and neck cancer invasion and metastasis in relation to MTA1.

show abstract

Section: Relevance Of Other Markers For Hnscc Carcinogenesismentioning

confidence: 99%

Role of MTA1 in head and neck cancers

Marzook

Deivendran

Kumar

et al. 2014

Cancer Metastasis Rev

Self Cite

View full text Add to dashboard Cite

show abstract

“…CD147 is expressed in epithelial cells [99], fibroblasts [123], psoriatic peripheral blood mononuclear cells [124], cytotrophoblasts [125], the normal basal epithelial layer reportedly harboring stem cells [126], ectopic endometrial tissues [127], systemic lupus erythematosus [128], synovial joint disease tissue of rheumatoid arthritis (RA) patients [115,129], plasma of lupus nephritis patients [130], peripheral monocytes and T lymphocytes of patients with ankylosing spondylitis [131]. …”

Section: The Expression and Role Of Cd147 In Tissues And Diseases mentioning

confidence: 99%

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Xiong

Edwards

Zhou

2014

IJMS

186

194

View full text Add to dashboard Cite

CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies.

show abstract

“…After dividing, the committed cells undergo differentiation that leads to the expression of structural keratin proteins as cells move superficially, and eventually fall off the surface. In the oral epithelium, it takes 14–24 days for a stem cell to divide and the progeny to traverse through the entire thickness of the epithelium (turnover time) [8]. Expression of several stem cells markers including, CD44, Bmi1, Sox2, Keratin 14, have been described mainly in the basal layer (Fig.…”

Section: Oral Mucosamentioning

confidence: 99%

“…However, the mechanism of tissue maintenance and regeneration is still largely unknown for these cells. It is interesting to note that no many studies have focused on transient amplifying (TA) progenitor cells in the oral cavity and on their potential to provide a reservoir for would healing and homeostasis [2, 5, 8, 14]. TA cells are slightly more differentiated than stem cells yet highly proliferative; they are derived from stem cells and continue to divide several times before undergoing terminal differentiation/maturation into the functional cells of the tissue; the size of the dividing transit population differs dramatically from tissue to tissue, the number of generations defining the degree of amplification that the transit population provides for each stem cells division seems to be related inversely to the frequency that stem cells will be found within the proliferating compartment [2,13].…”

Section: Oral Mucosamentioning

confidence: 99%

See 1 more Smart Citation

Oral epithelial stem cells—Implications in normal development and cancer metastasis

Papagerakis

Pannone

Zheng

et al. 2014

Experimental Cell Research

View full text Add to dashboard Cite

Oral mucosa is continuously exposed to environmental forces and has to be constantly renewed. Accordingly, the oral mucosa epithelium contains a large reservoir of epithelial stem cells necessary for tissue homeostasis. Despite considerable scientific advances in stem cell behavior in a number of tissues, fewer studies have been devoted to the stem cells in the oral epithelium. Most of oral mucosa stem cells studies are focused on identifying cancer stem cells (CSC) in oral squamous cell carcinomas (OSCCs) among other head and neck cancers. OSCCs are the most prevalent epithelial tumors of the head and neck region, marked by their aggressiveness and invasiveness. Due to their highly tumorigenic properties, it has been suggested that CSC may be the critical population of cancer cells in the development of OSCC metastasis. This review presents a brief overview of epithelium stem cells with implications in oral health, and the clinical implications of the CSC concept in OSCC metastatic dissemination.

show abstract

The stem cell code in oral epithelial tumorigenesis: ‘The cancer stem cell shift hypothesis’

Cited by 34 publications

References 155 publications

Role of MTA1 in head and neck cancers

Role of MTA1 in head and neck cancers

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Oral epithelial stem cells—Implications in normal development and cancer metastasis

Contact Info

Product

Resources

About