The status of rubella IgG antibody titer between antenatal and postnatal among pregnant non-immune to rubella

Rasool, Irfana; Azad, Ayesha; Baradwan, Saeed; Bashir, Muhammad Salman; Al‐Jaroudi, Dania

doi:10.1080/21645515.2020.1771077

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…14,17 Postpartum rubella vaccination strategy of susceptible females was established in the KFHU hospital, as many hospitals in the Kingdom, as two doses of MMR vaccine. 3,18 The first dose to be given to the mother in the post-partum period before discharge from the hospital, and the sec- In the present study, significant associations were found between susceptibility to rubella infection and nationality; non-Saudi had lower odds of susceptibility than their counterparts. The reason behind this difference could be that most of the non-Saudi workforce had the tests and vaccines preceding their recruitment, although occupation was not assessed in the study.…”

Section: Discussionmentioning

confidence: 46%

“…Moreover, older females might be tested during their previous pregnancies, had the postpartum vaccines, and consequently developed protective levels of rubella IgG during this study 14,17 . Postpartum rubella vaccination strategy of susceptible females was established in the KFHU hospital, as many hospitals in the Kingdom, as two doses of MMR vaccine 3,18 . The first dose to be given to the mother in the post‐partum period before discharge from the hospital, and the second dose at least 4 weeks apart in the nearest primary healthcare centre.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of rubella virus among pregnant women: A 4‐year registered‐based study from family medicine and obstetric clinics in Saudi Arabia

AlShamlan

AlOmar

Alotaibi

et al. 2021

Int J Clinical Practice

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Objectives This study aimed to determine rubella virus infectivity and immune status in pregnant females who visited the family medicine and obstetrics clinics at a large hospital in Saudi Arabia, and to identify the possible predictors of rubella susceptibility. Methods This registered‐based, cross‐sectional study included pregnant, aged between 18 and 50 years old, who presented for the first antenatal visit between 2017 and 2020. Data on sociodemographic, antenatal characteristics and serological results were collected. Chi‐Squared or Fisher's Exact test and t tests were used for bivariate analysis followed by the multivariable logistic regression model. Results A total of 4328 pregnant were included in the study. Seroprevalence of rubella immunity was 76.41%. Positive rubella IgM antibody was identified in 1.21% of those who performed the test (17/1409). Odds of susceptibility were decreased with an increase in age (OR = 0.96, 95% CI = 0.95‐0.97) and in non‐Saudis’ (OR = 0.44, 95% CI = 0.36‐0.54). Conclusions Approximately 24% of pregnant were susceptible to rubella virus infections in this study. Screening females of child‐bearing age and reimmunisation of susceptible cases before pregnancy are suggested. Further studies to investigate the impact of applying this policy in premarital screening are recommended.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Seroprevalence of rubella virus among pregnant women: A 4‐year registered‐based study from family medicine and obstetric clinics in Saudi Arabia

AlShamlan

AlOmar

Alotaibi

et al. 2021

Int J Clinical Practice

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show abstract

“…Most adults with rubella usually have a mild disease, with symptoms including fever, sore throat, red rash, nausea, and mild conjunctivitis 5 . The neonates infected with rubella usually have symptoms of red rash, low fever (<39°C), and some respiratory symptoms 6,7 . However, rubella is especially dangerous for pregnant women and their developing babies.…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology study of rubella virus antibodies among neonates and pregnant women at hospitals in Henan province, China

Wang,

Han,

et al. 2023

Journal of Medical Virology

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Rubella virus infection can cause vertical transmission to the fetus during pregnancy. In China's Henan province, rubella surveillance needs to be well‐established. In this research, a total of 1933 neonates and 2502 pregnant women were enrolled, and their sera for IgG and IgM antibodies against rubella were tested by chemiluminescence assay. Of 1933 neonates' sera tested, the seropositive of rubella IgG was 68.7%. The seroprevalence of rubella IgM in neonates was 0.4%. 30.9% of neonates had negative results for IgG and IgM antibodies. Two thousand five hundred and two pregnant women participated in the serosurvey, and 79.3% were rubella IgG positive. Rubella IgG seropositivity in pregnant women differed by age and number of births. 0.8% of the pregnant women had positive results for IgM against the rubella virus. The seronegative of rubella IgG and IgM antibodies in pregnant women was 19.8%. Due to the negative rubella‐specific IgG antibody, many neonates remain at risk of rubella virus infection. Rubella virus continues to spread since some neonates and pregnant women with rubella‐specific IgM antibody positive have been detected. Rubella vaccination may be introduced for childbearing‐age women to increase immunity levels against rubella with periodic sero‐surveillance.

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Rubella Humoral Immunity Among the Saudi Population of Madinah in the Western Region of Saudi Arabia

Ibrahim

Mahallawi

2022

Viral Immunology

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The status of rubella IgG antibody titer between antenatal and postnatal among pregnant non-immune to rubella

Cited by 3 publications

References 10 publications

Seroprevalence of rubella virus among pregnant women: A 4‐year registered‐based study from family medicine and obstetric clinics in Saudi Arabia

Seroprevalence of rubella virus among pregnant women: A 4‐year registered‐based study from family medicine and obstetric clinics in Saudi Arabia

Seroepidemiology study of rubella virus antibodies among neonates and pregnant women at hospitals in Henan province, China

Rubella Humoral Immunity Among the Saudi Population of Madinah in the Western Region of Saudi Arabia

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