The Status of Lipid Management in 1,836 Patients with Coronary Artery Disease: A multicenter survey to evaluate the percentage of Japanese coronary artery disease patients achieving the target low-density lipoprotein cholesterol level specified by the Japan Atherosclerosis Society

Nagashima, Hirotaka; Kasanuki, Hiroshi

doi:10.5551/jat.12.338

Cited by 15 publications

(13 citation statements)

References 23 publications

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“…The rate of statin therapy was higher than the result in Japan (36.3%). 27 A study of Hong Kong showed only 37% of the participants received the lipid lowering drugs. 28 Cooke and Hammerash's study reported lipid lowering therapy was only prescribed to 68.6% of their patients, with no significant sex differences (men vs women, 71.4% vs 63.3%).…”

Section: Resultsmentioning

confidence: 99%

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The Gender Differences in Baseline Characteristics and Statin Intervention Among Outpatients with Coronary Heart Disease in China: The China Cholesterol Education Program

2009

Clinical Cardiology

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The conservation status of western lowland gorillas and central chimpanzees in western equatorial Africa remains largely speculative because many remote areas have never been surveyed and the impact of emergent diseases in the region has not been well documented. In this study, we compared ape densities and habitats in the Lokoué study area in Odzala National Park and the Goualougo Triangle in Nouabalé‐Ndoki National Park in northern Republic of Congo. Both of these sites have long been considered strongholds for the conservation of chimpanzees and gorillas, but supposedly differ in vegetative composition and relative ape abundance. We compared habitats between these sites using conventional ground surveys and classified Landsat‐7 ETM+ satellite images. We present density estimates via both standing‐crop and marked‐nest methods for the first time for sympatric apes of the Congo Basin. The marked‐nest method was effective in depicting chimpanzee densities, but underestimated gorilla densities at both sites. Marked‐nest surveys also revealed a dramatic decline in the ape population of Lokoué which coincided with a local Ebola epidemic. Normal baseline fluctuations in ape nest encounter rates during the repeated passages of marked‐nest surveys were clearly distinguishable from a 80% decline in ape nest encounter rates at Lokoué. Our results showed that ape densities, habitat composition, and population dynamics differed between these populations in northern Congo. We emphasize the importance of intensifying monitoring efforts and further refinement of ape survey methods, as our results indicated that even the largest remaining ape populations in intact and protected forests are susceptible to sudden and dramatic declines. Am. J. Primatol. 70:439–451, 2008. © 2008 Wiley‐Liss, Inc.

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Section: Resultsmentioning

confidence: 99%

“…Reports showed the rate of achieving the target in patients with coronary heart disease was 29.9% in Japan 27 and 15% in Hong Kong. 28 Cooke and Hammerash's study indicted of the patients prescribed lipid lowering therapy (primarily statins), 53.8% of them achieved target (LDL-C of <2.60 mmol/L).…”

Section: Resultsmentioning

confidence: 99%

The Gender Differences in Baseline Characteristics and Statin Intervention Among Outpatients with Coronary Heart Disease in China: The China Cholesterol Education Program

2009

Clinical Cardiology

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“…Ezetimibe is effective as monotherapy 1,2) and is more potent in combination with HMG-CoA reductase inhibitors (statins), such as simvastatin 3) , lovastatin 4) , pravastatin 5) , and atorvastatin 6) . Recent study revealed that patients with coronary artery disease should be treated more strictly 7,8) . The activity of LDL receptors is enhanced by statins, which have almost no effect on the plasma cholesterol concentration of homozygous familial hypercholesterolemic patients because of the patients' total lack of LDL receptors.…”

Section: Introductionmentioning

confidence: 99%

Acute Inhibition of Lymphatic Cholesterol Transport in Rat Intestine by SCH 58053

Hayashi

Kanai

Yamada

et al. 2006

JAT

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To clarify the pharmacological mechanism of ezetimibe, SCH 58053, an analog of ezetimibe, was intraduodenally administered to lymph-fistula rats, and its effect on lymphatic lipid transport in the intestine was monitored. SCH 58053, 5.0 mg/kg body weight, was administered one hour before a 5-hour infusion of a lipid emulsion containing 40 mol/h of triolein and 2.74 mol/h of cholesterol (Experiment 1) or co-administered at 5.0 mg/kg body weight/h with the lipid emulsion for 4 hours to rats that had been infused with the lipid emulsion alone for 3 hours (Experiment 2). SCH 58053 administration significantly inhibited lymphatic cholesterol transport, but not triglyceride transport, in both groups compared to control rats that did not receive SCH 58053. The ratio of free cholesterol to total cholesterol in the lymph of the treated rats was unchanged compared to the control rats. Thus, the results showed that SCH 58053 is a potent, rapid, and selective inhibitor of lymphatic cholesterol transport in the intestine.

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“…Of the 148 patients in the present study, therefore, 65 patients (45 men, 20 women) received statins after CAG, and 83 (62 men, 21 women) did not receive statins after CAG. The statins administered to patients consisted of atorvastatin, fluvastatin, simvastatin, and pravastatin 12) .…”

Section: Introductionmentioning

confidence: 99%

Low Incidence of Cardiac Events in Statin-Administered Patients in CAG Study

Saeki

Sakuma

Hayakawa

et al. 2009

JAT

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Aim:The effect of statins in preventing cardiac events in Japanese coronary artery disease (CAD) patients was studied in a retrospective investigation of 148 patients diagnosed with CAD by coronary angiography (CAG). Methods: Sixty-five patients received statins within 2 weeks after CAG, and 83 patients did not receive statins after CAG. Results: In the statin group, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were reduced significantly with statin administration (p 0.01). In the non-statin group, baseline levels of TC, LDL-C and high-density lipoprotein cholesterol were not changed significantly at the end of the follow-up period. As for the effect of statin in preventing cardiac events, the incidence of cardiac events was significantly lower (p 0.0003) in the statin group (n 5: 8%) than in the nonstatin group (n 28: 34%). In subanalysis of 37 patients whose TC at the time of initial CAG was less than 200 mg/dL, none of the statin group (n 17) suffered a cardiac event. This was significantly lower than the incidence of cardiac events in the non-statin group (n 5: 25%; p 0.05). Conclusion:The present study demonstrated that lowering LDL-C of Japanese CAD patients by statin administration is effective to prevent cardiac events, particularly, a second percutaneous coronary intervention (PCI) for restenosis of a coronary artery following the initial PCI whether or not these patients had hypercholesterolemia.

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The Status of Lipid Management in 1,836 Patients with Coronary Artery Disease: A multicenter survey to evaluate the percentage of Japanese coronary artery disease patients achieving the target low-density lipoprotein cholesterol level specified by the Japan Atherosclerosis Society

Cited by 15 publications

References 23 publications

The Gender Differences in Baseline Characteristics and Statin Intervention Among Outpatients with Coronary Heart Disease in China: The China Cholesterol Education Program

The Gender Differences in Baseline Characteristics and Statin Intervention Among Outpatients with Coronary Heart Disease in China: The China Cholesterol Education Program

Acute Inhibition of Lymphatic Cholesterol Transport in Rat Intestine by SCH 58053

Low Incidence of Cardiac Events in Statin-Administered Patients in CAG Study

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