The status of in vivo autofluorescence spectroscopy and imaging for oral oncology

Veld, Diana C. G. de; Witjes, Max J. H.; Sterenborg, Henricus J. C. M.; Roodenburg, Jan

doi:10.1016/j.oraloncology.2004.07.007

Cited by 239 publications

(204 citation statements)

References 62 publications

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“…In recent years, autofluorescence of cancer was investigated based on the knowledge that some endogenous fluorophores in the tissues change when normal tissue turns malignant [10][11][12]. Autofluorescence imaging and spectroscopy is a non-invasive, label-free, real-time technique for cancer detection.…”

Section: Introductionmentioning

confidence: 99%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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Lung cancer is one of the most common cancers, with high mortality rate worldwide. Autofluorescence imaging and spectroscopy is a non-invasive, label-free, real-time technique for cancer detection. In this study, lung tissue sections excised from patients were detected by laser scan confocal microscopy and spectroscopy. The autofluorescence images demonstrated the cellular morphology and tissue structure, as well as the pathology of stained images. Based on the spectra study, it was found that the majority of the patients showed discriminating fluorescence in tumor tissues from normal tissues. Therefore, autofluorescence imaging and spectroscopy may be a potential method for aiding the diagnosis of lung cancer.

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Section: Introductionmentioning

confidence: 99%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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“…Thus, autofluorescence spectroscopy and imaging are helpful in diagnosis of lesions of the oral mucosa and has shown great promise for enhancing visualization of neoplastic areas. These studies assessed the limits of the lesions is clinically visible or not, however, few studies have evaluated the surgical margins of cancer lesions of the oral cavity [33,34], be a difference in our study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of surgical margins in oral cancer using in situ fluorescence spectroscopy

et al. 2014

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“…de Veld et al [42] observed that dysplastic sites and tumors are accompanied by a progressive drop in fluorescence intensity, whereas Lane et al [31] reported a loss of signal in wide field fluorescence images from potentially malignant and malignant oral lesions compared to normal mucosa around of the lesion. The reduced fluorescence associated with neoplasia was seen in a wide range of excitation wavelengths of 330-470 nm in the study of Schwarz et al [34].…”

Section: Discussionmentioning

confidence: 99%