The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma

Lin, Yen‐Ting; Wang, Wenyi; Lin, Jin‐Ching; Wong, Yong–Kie; Chien, Yi-Chih

doi:10.1016/j.oraloncology.2010.08.006

Cited by 1 publication

(5 citation statements)

References 24 publications

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“…In our study, we could not find an association between CA length and clinical outcome in patients with oral squamous cell carcinoma. This is in accordance with the results of another study of patients with oral cancer . However, comprehensive laboratory studies are needed to explore biological aspects of this issue.…”

Section: Discussionsupporting

confidence: 88%

“…confirmed the finding for homozygous oral cancer patients with only 10% overall and disease‐free survival after 2 yr. Ten of 47 patients were homozygous in their collective . In our cohort, 27 of 91 patients were homozygous and the most frequent genotype was 16–16 CA repeats, but we did not find a significant correlation between zygosity and survival or recurrence rate.…”

Section: Discussioncontrasting

confidence: 73%

“…Lin et al . discussed the possibility of an interethnic difference in the association between length and survival, as East Asian patients with breast cancer have longer CA repeats and lower expression of EGFR than White Europeans . Kang et al .…”

Section: Discussionmentioning

confidence: 99%

“…Tumor features and patient outcome did not differ significantly with respect to the lengths of the CA‐SSR‐1. However, patients with homozygous alleles had a significantly poorer outcome .…”

mentioning

confidence: 93%

“…Lin et al . studied a total of 47 Taiwanese patients with oral cancer. Tumor features and patient outcome did not differ significantly with respect to the lengths of the CA‐SSR‐1.…”

mentioning

confidence: 99%

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Lack of evidence for prognostic value of epidermal growth factor receptor intron‐1 CA repeats for oral carcinomas

Precht

Blessmann

Schön

et al. 2017

European J Oral Sciences

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Epidermal growth factor receptor (EGFR) expression is altered in several malignancies, including oral squamous cell carcinoma. A CA-repeat polymorphism in intron-1 (CA-SSR-1) of the EGFR gene is reported to influence EGFR expression and is associated with features of various solid tumors and outcomes of cancer patients. In the present study we evaluated the influence of length and zygosity of CA-SSR-1 on the survival of patients with oral squamous cell carcinoma. The length and zygosity of CA-SSR-1 was obtained through microsatellite analysis in 91 patients with oral cancer, who were treated in the Department of Oral and Maxillofacial Surgery of the University Medical Centre Hamburg Eppendorf, Germany, during the years 1998-2008. Follow up was conducted until 2016. Outcome measures were age, gender, tumor stage, occurrence of metastases, and date of recurrence or death. Statistical analysis was conducted using the chi-square test and the log-rank test. Neither length nor zygosity of the CA-SSR-1 in patients with oral squamous cell carcinoma was significantly correlated with sex, age, tumor size, tumor localization, lymph node involvement, metastasis status, disease-free survival, or overall survival. Length and zygosity of the CA-SSR-1 polymorphism in EGFR is not able to serve as a prognostic biomarker in White European patients with oral squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 93%

“…Lin et al . studied a total of 47 Taiwanese patients with oral cancer. Tumor features and patient outcome did not differ significantly with respect to the lengths of the CA‐SSR‐1.…”

mentioning

confidence: 99%

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