The Statistical Models Project (SMp) for Evaluations of Biological Radiation Effects

Abstract

This document provides probabilistic-mechanistic models for describing the cell kill (K) and cell sublethal damage (SL) for one fraction with a dose of radiation that is absorbed by a living tissue; also this provides the K and SL formalisms for fractioned irradiation regimens. These models and formalisms are based on real mean behavior of cell survival (S) -a complement of K-and strong probabilistic-radiobiological foundations. The K and SL formalisms include all possible factors affecting the biological radiation effects: dose (d), fractionations (n), SL, and the temporal factors: cell repair and cell repopulation. It is discussed some aspects about the widely used linearquadratic (LQ) S(d) model and LQ S(n,d) formalism, and one of its derivations, the BED (biologically effective dose). The SMp K(d) parameters can be obtained from S data, or using graphical/analytical tools developed by this study. These new formalisms will be useful for simulations of treatments, and together regional damage distribution for optimizations of the treatment planning. Keywords: BED, LQ model, stochastic effects, cell survivalCite This Article: Terman Frometa-Castillo, "The Statistical Models Project (SMp) for Evaluations of Biological Radiation Effects

Use of Exponential Functions in the Evaluations of Stochastic Variables in the Ionizing Radiation Field

“…(6) unnecessary. The SMp type P2 was used in (Frometa-Castillo, 2017b) for determining the SMp cell sublethal damage model.…”