The state of the immune system of dogs in experimental toxocariasis

Said, W. S.; Stybel, V. V.; Gutyj, B. V.; Pryima, O. B.; Sobolta, A.; Leskiv, K. Y.; Dytiuk, M. P.

doi:10.32718/ujvas3-3.04

Cited by 4 publications

(3 citation statements)

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“…За останнє десятиліття у зв'язку з прогресивним зростанням чисельності собак, їх безконтрольним утриманням і масовим забрудненням навколишнього середовища інвазійним матеріалом -фекаліями, дане захворювання стало серйозною медико-соціальною проблемою для багатьох країн світу, зокрема, і України Said et al, 2020).…”

Section: вступunclassified

Effect of fenbenzyl and fenbendazole on peroxide intensity oxidation of lipids in the blood of dogs in experimental toxocariasis

2021

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Toxocariasis is a chronic helminthic disease caused by the larval stages of the nematode Toxocara canis. The problem of toxocariasis is important for both humane and veterinary medicine. Therefore, the aim of the study was to investigate the effect of fenbenzyl and fenbendazole on the intensity of lipid peroxidation in the blood of dogs during experimental infestation with the pathogen toxocariasis. The experiments were performed on 18 dogs, two to four months of age, and three groups of six animals were formed in each: control and two experimental groups. Puppies of all groups were experimentally infected with the pathogen toxocariasis at a dose of 5.000 invasive T. canis eggs per kg of body weight. The control group of dogs was as untreated control. Puppies of the first experimental group were fed the drug “Fenbendazole” at a dose of 150 mg per 3 kg of animal weight once a day for three days in a single dose. Puppies of the second experimental group were fed the drug “Fenbenzyl” at a dose of 350 mg per 3 kg of animal weight once a day for three days. In the clinical manifestation of the disease, toxocariasis secretes metabolic products that promote the formation of large amounts of free radicals, which in turn enhance the initiation of lipid peroxidation processes. With the use of fenbendazole and fenbenzyl, a probable decrease in these products was found starting from the 15th day of the experiment. It should be noted that the lowest level of diene conjugates and TBA-active products was in the blood of dogs of the second experimental group at 25 and 30 days of the experiment. Inhibition of lipid peroxidation processes in the treatment of dogs with fenbenzyl is due to the activation in animals of metabolic processes involving enzymes, including antioxidant enzymes that catalyze the processes of peroxidation and phosphorylation, as well as enhancing erythropoietic function. On the 30th day of the experiment, the level of diene conjugates in the blood of the second experimental group was 0.29 ± 0.02 IU/ml, and TBA-active products – 25.2 ± 0.40 μmol/l.

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Effect of fenbenzyl and fenbendazole on peroxide intensity oxidation of lipids in the blood of dogs in experimental toxocariasis

2021

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“…У подальшому з віком собак показники їх інвазованості знижувалися (25 % у віці від 1-го до 2-х років). Найнижчий рівень інвазованості зареєстровано в дорослих тварин, переважно у вагітних самок віком понад 3 роки (11 %) (Stybel & Pryima, 2010;Said et al, 2020).…”

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Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

et al. 2020

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The aim of the study was to investigate the effect of toxocariasis invasion on protein-synthesizing function and functional state of the liver of dogs. For experimental studies, 12 dogs aged from two to four months were used and two groups of six animals were formed in each: control and experimental. Puppies of the experimental group were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive eggs of T. canis per kg of body weight. The control puppies were clinically healthy. Protein-synthesizing function of the liver of dogs in experimental toxocariasis was studied by the level of total protein and its fractions. It was found that on the 25th day of the experiment the level of total protein in the blood of the experimental group of dogs was 56.9 ± 1.47 g/l, while in the control group – 63.8 ± 2.92 g/l. The lowest level of the studied indicator was on the 30th day of the experiment in the blood of the experimental group of dogs, where it decreased by 9.6 %. The results of a study of protein fractions in the blood of dogs infested with toxocara showed that the percentage of albumin is likely to decrease. However, in the blood of infected dogs in this period of research there was a probable increase in globulin levels. The study of the effect of toxocariasis invasion on the activity of enzymes in blood serum is a test for the morphological and functional state of tissues and organs. Based on the studies, it was found that with the development of toxocariasis invasion in dogs there is an increase in alanine aminotransferase in their serum. On the 25th and 30th day of the experiment, the activity of the enzyme in the serum of infected dogs was the highest, where compared with the control group of dogs, the activity of ALT increased by 51.2 and 59.1 %, respectively. Similar changes in activity were observed in the determination of aspartate aminotransferase, where, respectively, on the 15th, 20th and 25th day of the experiment, the activity of AST in the serum of infected dogs increased by 19.3, 27.5 and 39.1 %.

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“…As a result of the application of anthelmintic drugs for treating animals with toxocariasis, side effects caused by the reaction of dogs to the death of Toxocara can occur, because the destruction of Toxocara also leads to the release of toxins (Rubinsky-Elefant et al, 2011;Zakharchuk & Harazdiuk, 2014;Noor et al, 2019;Said et al, 2020).…”

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Effect of Fenbenzyl and Fenbendazole on the Antioxidant Status in Dogs During Experimental Infection With Causative Agent of Toxocariasis

Stybel

Gutyj

Said

et al. 2021

Ukrainian journal of veterinary sciences

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The ar cle presents the results of studies of the effect of fenbenzyl and fenbendazole on the an oxidant status in dogs under the experimental infec on with a causa ve agent of toxocariasis. Experiments were performed on 18 dogs, two and four months old. Three groups of six animals in each were formed: control and two experimental. Puppies in all groups were experimentally infected with causa ve agent of toxocariasis at a dose of 5.000 embryonated Toxocara canis eggs per kg of body weight. The control group of dogs was as untreated control. Puppies of the first experimental group were fed with the drug fenbendazole at a dose of 150 mg per 3 kg of body weight once a day for three days in a single dose. Puppies of the second experimental group were fed with the drug fenbenzyl at a dose of 350 mg per 3 kg of body weight once a day for three days. While studying the ac vity of the enzyma c part of the an oxidant defense system, namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, as well as a non-enzyma c part: the level of reduced glutathione, an increase in the ac vity of these indicators was found in animals of experimental groups. It should be noted that the applica on of the drug fenbenzyl in infected dogs contributed to a be er normaliza on of the an oxidant system in animals than the use of the drug fenbendazole. The use of fenbenzyl in infected dogs contributed to a more likely increase in the an oxidant status in dogs of the second experimental group, as this drug includes milk thistle that exhibits an oxidant proper es due to the presence of silymarin, which restores damaged liver cells. Studies confirm the effec veness of the use of milk thistle in drug fenbenzyl in dogs with the development of toxocariasis infec on to ac vate the protec ve systems of their body.

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The state of the immune system of dogs in experimental toxocariasis

Cited by 4 publications

References 10 publications

Effect of fenbenzyl and fenbendazole on peroxide intensity oxidation of lipids in the blood of dogs in experimental toxocariasis

Effect of fenbenzyl and fenbendazole on peroxide intensity oxidation of lipids in the blood of dogs in experimental toxocariasis

Protein-synthesizing function and functional state of the liver of dogs at experimental toxocariasis

Effect of Fenbenzyl and Fenbendazole on the Antioxidant Status in Dogs During Experimental Infection With Causative Agent of Toxocariasis

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