The State of Art on Co-Morbid Insomnia and Sleep Apnea (COMISA)

Gennaro, Luigi De

doi:10.3390/brainsci11081079

Cited by 2 publications

(3 citation statements)

References 4 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in the present study, the prevalence of COMISA in this initial study was markedly lower than the prevalence reported for adults, i.e., ~39% (De Gennaro, 2021; Lundetræ et al, 2021; Meira E Cruz et al, 2021a; Smith et al, 2004; Sweetman et al, 2021a, 2021b; Wallace & Wohlgemuth, 2019). Furthermore, Sweetman et al (2021a, 2021b) observed in their sample that 60% of the patients in the group with symptoms of COMISA were male ( p < 0.001), whereas in the present study there was no significant difference in the frequency between boys and girls.…”

Section: Discussioncontrasting

confidence: 59%

“…It has become clear that COMISA represents a clear pattern of bidirectional relationships between the two different disorders (De Gennaro, 2021). Studies have shown that the prevalence of COMISA varies according to the initial point of observation, that is, 35% of patients with insomnia will have moderate sleep apnea, while 38% of patients with OSA meet the criteria for insomnia (Sweetman et al, 2021a(Sweetman et al, , 2021b.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comorbid insomnia and sleep apnea in children: a preliminary explorative study

Cruz

Salles

Seixas

et al. 2022

Journal of Sleep Research

View full text Add to dashboard Cite

Insomnia and sleep-disordered breathing (SDB) are prevalent sleep disorders. These disorders can therefore be concurrently presentcomorbid insomnia and sleep apnea (COMISA). The prevalence of COMISA in the paediatric age range is unclear.As such, phenotypic constructs should help better define this comorbid condition if it exists in children and improve both diagnostic sensitivity and ultimately clinical care outcomes. We aimed to evaluate the frequency of insomnia in children and adolescents referred for evaluation of sleep symptoms suggestive of SDB in one initial (Cohort#1) and verify such findings in an independent cohort (Cohort#2) using a retrospective cross-sectional approach in patients aged 9-19 years presenting at a sleep centre to be evaluated for symptoms of SDB. Cohort #1 comprised 50 consecutive children (58% males; mean [SD] age 13.6 [3.3] years; median [interquartile range, IQR] Epworth Sleepiness Scale score 10 [6-12]) who were evaluated using validated SDB and insomnia questionnaires. Cohort#2 was extracted from electronic medical records and included 384 polysomnographically evaluated children (mean [SD] age 12.9 [3.6] years; mean [SD] body mass index z score 1.27 [0.28]; median Epworth Sleepiness Scale score 9. 7 [4-17]). In Cohort #1, 56% were at high risk of SDB, 36% had insomnia alone, and 18% were at high risk of COMISA. The prevalence of COMISA in Cohort #2 was 16%, 72% had SDB alone, and 12% had insomnia alone.In both cohorts, COMISA manifested as increased propensity for sleepiness and fatigue during both waking and daytime. Thus, the presence of COMISA is frequent in the paediatric age range and accompanied by a more prominent symptomatic phenotype.

show abstract

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Comorbid insomnia and sleep apnea in children: a preliminary explorative study

Cruz

Salles

Seixas

et al. 2022

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…Thus, that may have caused us to underestimate the OSA prevalence or injury incidence, and we could not exclude the individuals without OSA diagnosis in the control group who were actually victims of OSA. Fourth, OSA and insomnia are two prevalent sleep disorders, and they often coexist interacting to amplify an overall more severe illness [54][55][56]. A recent study reported the prevalence of comorbid insomnia and OSA (COMISA); 35% of insomnia patients have an AHI of ≥5, and 29% have an AHI of ≥15, while 38% of patients with OSA meet insomnia criteria [57].…”

Section: Discussionmentioning

confidence: 99%

Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study

Cheng

Chung

et al. 2021

IJERPH

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) has been reported to increase the risk of motor vehicle accidents. However, only few studies have investigated the effects of OSA on overall risk injury. The aim of study is to investigate whether OSA increases the risk of overall injury. The data were collected during 2000–2015 from Taiwan’s National Health Insurance Research Database. A total of 8901 individuals diagnosed with OSA were inpatients, or outpatients at least three times were enrolled. Finally, 6915 participants with OSA were included as the study cohort. We matched the study cohort with a comparison cohort, at a ratio of 1:4. Cox proportional hazards regression was used to analyse the association between OSA and overall injury. Patients with OSA had 83.1% increased risk of overall injury, compared to non-OSA individuals [adjusted hazards ratio (HR) = 1.831, confidence interval (CI) = 1.674–2.020, p < 0.001]. In the stratified age group, patients aged ≧65 years had the highest risk of injury (adjusted HR= 2.014; CI = 1.842–2.222, p < 0.001). Patients with OSA were at a higher risk of falls, traffic injury, poisoning, suffocation, suicide, and abuse or homicide than non-OSA individuals, with falls and traffic injury as the leading causes of injuries. The data demonstrated that patients with OSA have a higher risk of overall injury. The study results can be a reference for developing injury prevention strategies in the future. The general population and clinicians should have more awareness regarding OSA and its negative effects on injury development.

show abstract

The State of Art on Co-Morbid Insomnia and Sleep Apnea (COMISA)

Abstract: Insomnia and obstructive sleep apnea (OSA) are two prevalent sleep disorders which share nocturnal sleep disturbances, impairments to daytime activity and quality of life, and high healthcare and social costs [...]

Cited by 2 publications

References 4 publications

Comorbid insomnia and sleep apnea in children: a preliminary explorative study

Comorbid insomnia and sleep apnea in children: a preliminary explorative study

Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study

Contact Info

Product

Resources

About