The Staphylococci Phages Family: An Overview

Deghorain, Marie; Melderen, Laurence Van

doi:10.3390/v4123316

Cited by 168 publications

(170 citation statements)

References 100 publications

(233 reference statements)

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“…Phage S6 was shown to belong to the family Myoviridae with a genome size of ca. 270 kbp (Andrew et al, 2011;Deghorain and Van Melderen, 2012;Figures 1a and b and Supplementary Table S2). Uracil was used as a nucleic acid base instead of thymine in the DNA of phage S6 (Supplementary Figure S1).…”

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confidence: 99%

Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage

et al. 2014

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Bacteriophage (phage)-mediated generalized transduction is expected to contribute to the emergence of drug-resistant staphylococcal clones in various environments. In this study, novel phage S6 was isolated from sewage and used to test generalized transduction in human-and animal-derived staphylococci. Phage S6 was a novel type of giant myophage, which possessed a DNA genome that contained uracil instead of thymine, and it could infect all of the tested staphylococcal species. The phage S6 appeared to be similar to the transducing phage PBS1, which infects Bacillus spp. Moreover, phage S6 facilitated the transduction of a plasmid in Staphylococcus aureus and from S. aureus to non-aureus staphylococcal species, as well as vice versa. Transduction of methicillin resistance also occurred in S. aureus. This is the first report of successful intragenus generalized transduction among staphylococci.

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Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage

et al. 2014

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“…To date, more than 68 Staphylococci phages and prophages' sequences, mainly from S. aureus, are identified [5].…”

Section: Introductionmentioning

confidence: 99%

“…S. aureus can produce more than 30 different extracellular proteins [1]. Most of them have been described and characterized, such as the staphylokinase (SAK), the chemotaxis inhibitory protein (CHIP), the staphylococcal inhibitor of complement (SCIN), and several superantigens including SEA, SEG, SEK, SEP, and SEQ [5,6]. These superantigens are enterotoxin.…”

Section: Introductionmentioning

confidence: 99%

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Identification of virulence genes carried by bacteriophages obtained from clinically isolated methicillin-resistant Staphylococcus aureus

Karasartova

Cavusoglu

Turegun

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Bacteriophages play an important role in the pathogenicity of Staphylococcus aureus (S. aureus) either by carrying accessory virulence factors or several superantigens. Despite their importance, there are not many studies showing the actual distribution of the virulence genes carried by the prophages obtained from the clinically isolated Staphylococcus. In this study, we investigated prophages obtained from methicillin-resistant S. aureus (MRSA) strains isolated from hospital-and community-associated (HA-CA) infections for the virulence factors. In the study, 43 phages isolated from 48 MRSA were investigated for carrying toxin genes including the sak, eta, lukF-PV, sea, selp, sek, seg, seq chp, and scn virulence genes using polymerase chain reaction (PCR) and Southern blot. Restriction fragment length polymorphism was used to analyze phage genomes to investigate the relationship between the phage profiles and the toxin genes' presence. MRSA strains isolated from HA infections tended to have higher prophage presence than the MRSA strains obtained from the CA infections (97% and 67%, respectively). The study showed that all the phages with the exception of one phage contained one or more virulence genes in their genomes with different combinations. The most common toxin genes found were sea (83%) followed by sek (77%) and seq (64%). The study indicates that prophages encode a significant proportion of MRSA virulence factors.

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“…Thus, MRSA pathogens can be targeted by the anti-S. aureus phages such as phage K and φMR11 [34,40]. φMR11, administrated intraperitoneally, appeared rapidly in the circulation of mice challenged with fatal S. aureus infection and successfully protected mice without any adverse effects [34].…”

Section: Phage Therapy Against Mrsamentioning

confidence: 99%

Physiology and Pathology of Multidrug-Resistant Bacteria: Phage-Related Therapy

Jiang¹,

Saxena²,

Wu³

2017

Physiology and Pathology of Immunology

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Multidrug-resistant bacteria (MDR) are spreading rapidly across the world that outpace development of new antibiotics. Options other than antibiotics treatment are urgently needed. In this chapter, we review the current status of nonantibiotics-based strategies including phage therapy and phage-derived protein therapy for targeting Gram-positive strains (methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium) and MDR Gram-negative strains (Acinetobacter baumannii and Pseudomonas aeruginosa).

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The Staphylococci Phages Family: An Overview

Cited by 168 publications

References 100 publications

Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage

Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage

Identification of virulence genes carried by bacteriophages obtained from clinically isolated methicillin-resistant Staphylococcus aureus

Physiology and Pathology of Multidrug-Resistant Bacteria: Phage-Related Therapy

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