2000
DOI: 10.1016/s0966-842x(00)01728-5
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The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

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Cited by 90 publications
(54 citation statements)
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“…Cell surface-associated glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) of S. epidermidis, S. pyogenes, S. pneumoniae, and Candida albicans have been reported (4,17,20,49). On S. epidermidis, GAPDH was found to act as a transferrin-binding protein on the cell surface (42,43). In S. pyogenes, GAPDH on the cell surface binds fibronectin, lysozyme, and the cytoskeletal proteins myosin and actin (49).…”
Section: Discussionmentioning
confidence: 99%
“…Cell surface-associated glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) of S. epidermidis, S. pyogenes, S. pneumoniae, and Candida albicans have been reported (4,17,20,49). On S. epidermidis, GAPDH was found to act as a transferrin-binding protein on the cell surface (42,43). In S. pyogenes, GAPDH on the cell surface binds fibronectin, lysozyme, and the cytoskeletal proteins myosin and actin (49).…”
Section: Discussionmentioning
confidence: 99%
“…The inability of the bacteria to grow at low initial densities in the presence of partially saturated transferrin suggests that iron displacement from transferrin requires high bacterial density. It has been suggested that diphosphoglycerate, whose formation is catalysed by the transferrin receptor glyceraldehyde-3-phosphate dehydrogenase, may facilitate iron removal from the receptor-bound transferrin [13]. Diphosphoglycerate and other organic phosphates were previously shown to displace iron from transferrin at millimolar concentrations [22].…”
Section: Discussionmentioning
confidence: 99%
“…iron-saturated transferrin) and lactoferrin (also known as lactotransferrin) on the surface of a diverse range of cell types, including macrophages, and upon iron starvation many cells prefer to use surfacelocalized GAPDH for holotransferrin uptake rather than TfR1 Modun et al, 1998;Modun et al, 2000;Raje et al, 2007;Rawat et al, 2012). Recently, we have also demonstrated that cells enhance their secretion of GAPDH into the extracellular milieu (sGAPDH) when they are depleted of iron.…”
Section: Introductionmentioning
confidence: 99%