The Staphylococcal Scalded-Skin Syndrome

Melish, Marian E.; Glasgow, Lowell A.

doi:10.1056/nejm197005142822002

Cited by 373 publications

(86 citation statements)

References 8 publications

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“…123,125 This has been attributed to the ability of adults to metabolize and excrete exfoliatin rapidly or to acquired immunity. 126 Localized bullous impetigo occurs in neonates and children. In neonates, lesions are found mostly on the perineum, periumbilical area, or both, while in older children, they are found most often on the extremities.…”

Section: Desmogleinmentioning

confidence: 99%

Desmosome assembly, homeostasis, and desmosomal disease

Cirillo¹

2016

CHC

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Cell-cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis (regulation of cell shape, apoptosis, cell movement, and development of complex structures) to aging and disease. A major player in the dynamic regulation of intercellular contacts is the desmosome. Knowledge of the desmosome has evolved over 150 years from the notion of a static, punctuate, adhesive barrier structure to one of the finely tuned multifunctional complexes involved in the regulation of numerous and diverse aspects of keratinocyte physiology and disease. In this context, nondesmosomal regulatory molecules have been acquiring increasing importance in the study of desmosome homeostasis and have become part of the extended desmosomal interactome named "desmo-adhesome". Among these associated molecules, kinases are the prominent regulators of both desmosome remodeling and acquisition of hyperadhesion, two novel concepts in cell-cell adhesion. Spatiotemporal changes in the expression and regulation of desmosomal proteins also underlie a number of genetic, infectious, autoimmune, and malignant conditions. In addition to offering a systems-level view of the molecular composition of desmosomes, we also discuss the mechanisms that regulate, and disrupt, desmosome homeostasis.

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Section: Desmogleinmentioning

confidence: 99%

Desmosome assembly, homeostasis, and desmosomal disease

Cirillo¹

2016

CHC

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“…25 This reaction was observed whether the staphylococci isolated were from cases exhibiting generalised exfoliation, bullous impetigo or only scarlatiniform rash. These manifestations of disease were assumed to represent the spectrum of clinical responses to infection with the same organism.…”

Section: A and B (Table 111) The Distinction Between Groups Amentioning

confidence: 99%

Staphylococcal scalded skin syndrome

Gemmell

1995

Journal of Medical Microbiology

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“…aureus strains 182, P78, PGll4, TG, and 689 have been previously described (Kapral and Miller, 1971;Kapral and Shayegani, 1959;Melish and Glasgow, 1970). Strains 182 and P78 produced both the a and 6 toxins, whereas strain TG elaborated a, /?…”

Section: Staphylococcal Strainsmentioning

confidence: 99%

Survival of Staphylococcus aureus in intraperitoneal abscesses

Dye¹,

Kapral²

1981

Journal of Medical Microbiology

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SUMMARY. An examination of 10 strains of Staphylococcus aureus for survival within abscesses developing in the peritoneal cavity of mice revealed three distinct patterns of survival. Although non-haemolytic mutants were destroyed more rapidly than were their parent strains, this difference could not be attributed to any particular haemolysin. In abscesses generated with mixtures of non-haemolytic variants and their parent strains, the former were preferentially eliminated; this suggests that the non-haemolytic variants were inherently more sensitive to the conditions within these lesions. Subsequent studies confirmed that abscess homogenates were cidal for staphylococci and that this activity resided in the insoluble fraction of the homogenates. Staphylococci added to abscess homogenates were killed, but only after a lag. This lag could be shortened or eliminated by incubating homogenates before adding the test organism. After development of a suitable assay, it was found that the cidal activity in abscess homogenates could be increased 3-20-fold by pre-incubation. Staphylococcal strains differed in their relative sensitivities to the cidal material; those strains rapidly destroyed within abscesses were the most sensitive and strains capable of better survival were more resistant. The results support the concept that the cidal material is responsible for destruction of staphylococci within such lesions.

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The Staphylococcal Scalded-Skin Syndrome

Cited by 373 publications

References 8 publications

Desmosome assembly, homeostasis, and desmosomal disease

Desmosome assembly, homeostasis, and desmosomal disease

Staphylococcal scalded skin syndrome

Survival of Staphylococcus aureus in intraperitoneal abscesses

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