The Standardization of Bee Venom Solutions

Mraz, Charles

doi:10.1080/0005772x.1962.11096962

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“…Bee venom is regularly used for the certain forms of arthritis and rheumatism therapy in some countries (Mraz, 2015). Considering the growing number of users and the commercial development of bee venom and related supplements as anti-inflammatory treatment, exploring the comprehensive protection of bee venom extract-Mel is urgently needed.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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Melittin (Mel), a natural detergent, is a major component of bee venom. Mel exhibits favorable clinical effects on the treatment of rheumatoid osteoarthritis, myositis, lumbar muscle strain, and peripheral neurological disorders. Interleukin-1β (IL-1β) contributes to the progression of osteoarthritis and is one of the key proinflammatory cytokines. However, the effect of Mel on IL-1β-induced osteoarthritis has not been reported. We examined the effects of Mel on the expressions of inducible NO synthase (iNOS), nuclear transcription factor κB (NF-κB), and I kappa B (I-κB) in the knee joint cells of C518 rats induced by IL-1β. Western blot and qPCR results showed that Mel at 0.1µg/mL or higher significantly inhibited iNOS expression. Similarly, 1µg/mL of Mel prevented IL-β-induced I-κB degradation in the cytoplasm and NF-κB migration from cytoplasm to nucleus. Mel exerts an inhibitory effect on IL-β-induced NF-κB activation by inhibiting both I-κB degradation and NF-κB migration and can potentially be developed as a new antiosteoarthritis drug. Further research is needed to clarify the detailed mechanism.

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Section: Discussionmentioning

confidence: 99%

Untitled

2021

Pak. J. Pharm. Sci

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The Standardization of Bee Venom Solutions

Cited by 1 publication

References 1 publication

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