The stability of sleep eeg microstructure and vigilance measures across two consecutive nights of laboratory polysomnography in cognitively normal older adults

Association between early stage N2 sleep spindle burst characteristics and vigilance groups: an observational study on patients from a tertiary sleep centre

“…Our results indicated that Sp characteristics can be mapped to vigilance outcomes in an OSA cohort. Models incorporating the Sp burst features outperformed the Mullins et al (2019), but our methods differ in a number of significant ways: (i) a larger (n = 250) population of subjects was used, representing a natural sample of subjects attending for routine diagnostic PSG in a sleep lab; (ii) a range of predictive mathematical models were developed, tested and compared in a cross-validation framework; (iii) novel and existing features such as Sp density were explored and used via an unsupervised clustering approach (Zhang et al 1996). In particular, our work proposed and evaluated a new class of features describing the burst structure of Sp across different sleep periods.…”

“…A relationship between vigilance and Sp has been investigated by several groups. In a small pilot study Mullins et al (2019) demonstrated that spindle density in NREM sleep may correlate with vigilance loss in OSA. Their pioneering work used a selected, small sample (n=8) of obese, older males, with severe OSA, imposed 40 h of acute sleep deprivation and provided descriptive statistics of the available data set.…”