The stability of horizontal ocular alignment of triad exotropia after one-step triple surgery

Wu, Lianqun; Xia, Weiyi; Li, Lei; Xi, Sida; Wang, Xiying; Wen, Wen; Jiang, Chao; Li, Guohua; Zhao, Chunxia

doi:10.1007/s00417-019-04599-2

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Among previous studies investigating Helveston syndrome, Ha et al reported a success rate of 57.1% [5], whereas Wu et al reported a success rate of 53.3%, with a small amount of eso-drift in the primary position postoperatively [6]. The overall success rate in the present study was 86.5%, which is higher than those of previous studies; no SO palsy, postoperative inverted V pattern, or induced extorsion were noted.…”

Section: Discussioncontrasting

confidence: 61%

“…The decision of surgical management of this triad is quite challenging; the treatment plan aimed at achieving postoperative ocular movement coordination should consider the possible complications and unpredictable outcomes of the surgery. However, existing reports suggest different surgical approaches and variable outcomes of each surgery [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of Helveston syndrome (Triad exotropia)

et al. 2021

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Purpose To evaluate and compare different surgical approaches for the treatment of Helveston syndrome and provide further information for preoperative planning. Methods From February 2008 to December 2018, data of 52 patients with Helveston syndrome were retrospectively reviewed. Different surgical approaches were selected based on the extent of A-pattern exotropia, dissociated vertical deviation (DVD), and both superior oblique muscle overaction (SOOA) with fundus photograph intorsion. Eye position, A-pattern, DVD, superior oblique muscle function, and binocular vision function were evaluated pre- and postoperatively. The average follow-up duration was 20.5 months. Results Nine cases underwent simultaneous horizontal deviation correction with bilateral superior rectus recession, 24 underwent simultaneous horizontal deviation correction with bilateral superior oblique muscle lengthening, and 19 underwent two stages of horizontal deviation correction with superior oblique muscle lengthening, and later bilateral superior rectus recession. A-pattern, DVD, SOOA, and fundus intorsion were all collapsed in all patients postoperatively. Forty-five patients had an orthophoric eye position with considerably aligned ocular movements postoperatively. The total success rate was 86.5%. Postoperatively, eight of the 10 patients with diplopia experienced a recovery of binocular single vision and three had a recovery of rudimentary stereopsis (Titmus 3000–400 s of arc). The compensatory head posture of patients improved significantly postoperatively. Conclusions The surgical planning of Helveston syndrome should be designed based on the degree of the A-pattern, SOOA, DVD, and the intorsion in fundus photographs, and the appropriate approach should be selected to improve patient satisfaction.

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Section: Discussioncontrasting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Surgical management of Helveston syndrome (Triad exotropia)

et al. 2021

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“…All patients have gone through a complete ocular examination, as well as sensory and motor evaluation, as previously published ( Wu et al, 2020a ). In brief, a prism alternating cover test (PACT) was applied to measure the horizontal and vertical deviations.…”

Section: Methodsmentioning

confidence: 99%

The profiles and clinical significance of extraocular muscle-expressed lncRNAs and mRNAs in oculomotor nerve palsy

Wu,

Shi,

Liang

et al. 2023

Front. Mol. Neurosci.

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IntroductionOculomotor nerve palsy (ONP) arises from primary abnormalities in the central neural pathways that control the extraocular muscles (EOMs). Long non-coding RNAs (lncRNAs) have been found to be involved in the pathogenesis of various neuroparalytic diseases. However, little is known about the role of lncRNAs in ONP.MethodsWe collected medial rectus muscle tissue from ONP and constant exotropia (CXT) patients during strabismus surgeries for RNA sequencing analysis. Differentially expressed mRNAs and lncRNAs were revealed and included in the functional enrichment analysis. Co-expression analysis was conducted between these differentially expressed mRNAs and lncRNAs, followed by target gene prediction of differentially expressed lncRNAs. In addition, lncRNA-microRNA and lncRNA-transcription factor-mRNA interaction networks were constructed to further elaborate the pathological changes in medial rectus muscle of ONP. Furthermore, RT-qPCR was applied to further validate the expression levels of important lncRNAs and mRNAs, whose clinical significance was examined by receiver operating characteristic (ROC) curve analysis.ResultsA total of 618 differentially expressed lncRNAs and 322 differentially expressed mRNAs were identified. The up-regulated mRNAs were significantly related to cholinergic synaptic transmission (such as CHRM3 and CHRND) and the components and metabolism of extracellular matrix (such as CHI3L1 and COL19A1), while the down-regulated mRNAs were significantly correlated with the composition (such as MYH7 and MYL3) and contraction force (such as MYH7 and TNNT1) of muscle fibers. Co-expression analysis and target gene prediction revealed the strong correlation between MYH7 and NR_126491.1 as well as MYOD1 and ENST00000524479. Moreover, the differential expressions of lncRNAs (XR_001739409.1, NR_024160.1 and XR_001738373.1) and mRNAs (CDKN1A, MYOG, MYOD1, MYBPH, TMEM64, STATH, and MYL3) were validated by RT-qPCR. ROC curve analysis showed that lncRNAs (XR_001739409.1, NR_024160.1, and NR_002766.2) and mRNAs (CDKN1A, MYOG, MYOD1, MYBPH, TMEM64, and STATH) might be promising biomarkers of ONP.ConclusionsThese results may shed light on the molecular biology of EOMs of ONP, as well as the possible correlation of lncRNAs and mRNAs with clinical practice.

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“…Before surgery, each patient underwent a complete ocular examination as well as sensory and motor evaluation as previously published [ 20 ]. In brief, a prism alternating cover test (PACT) was used to measure the horizontal and vertical deviations.…”

Section: Methodsmentioning

confidence: 99%

Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy

Shi,

Fang,

Liang

et al. 2023

BMC Genomics

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Background Oculomotor nerve palsy (ONP) is a neuroparalytic disorder resulting in dysfunction of innervating extraocular muscles (EOMs), of which the pathological characteristics remain underexplored. Methods In this study, medial rectus muscle tissue samples from four ONP patients and four constant exotropia (CXT) patients were collected for RNA sequencing. Differentially expressed circular RNAs (circRNAs) were identified and included in functional enrichment analysis, followed by interaction analysis with microRNAs and mRNAs as well as RNA binding proteins. Furthermore, RT-qPCR was used to validate the expression level of the differentially expressed circRNAs. Results A total of 84 differentially expressed circRNAs were identified from 10,504 predicted circRNAs. Functional enrichment analysis indicated that the differentially expressed circRNAs significantly correlated with skeletal muscle contraction. In addition, interaction analyses showed that up-regulated circRNA_03628 was significantly interacted with RNA binding protein AGO2 and EIF4A3 as well as microRNA hsa-miR-188-5p and hsa-miR-4529-5p. The up-regulation of circRNA_03628 was validated by RT-qPCR, followed by further elaboration of the expression, location and clinical significance of circRNA_03628 in EOMs of ONP. Conclusions Our study may shed light on the role of differentially expressed circRNAs, especially circRNA_03628, in the pathological changes of EOMs in ONP.

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The stability of horizontal ocular alignment of triad exotropia after one-step triple surgery

Cited by 5 publications

References 25 publications

Surgical management of Helveston syndrome (Triad exotropia)

Surgical management of Helveston syndrome (Triad exotropia)

The profiles and clinical significance of extraocular muscle-expressed lncRNAs and mRNAs in oculomotor nerve palsy

Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy

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