The stability constant of complex

Levin, Victoria; Gracheva, Maria; Ilyushchenko, O.N.

doi:10.1016/0020-708x(80)90131-3

Cited by 13 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover the indium chelates using polyaminocarboxylate ligands are more stable than the technetium chelates (Table 1). 32,33 In contrast to the radiolabelling of Au@DTDTPA by 99m Tc, the immobilization of 111 In within the DTDTPA shell of the gold nanoparticles does not need the change of oxidation state of the radionuclide. The labelling of Au@DTDTPA nanoparticles by 111 In consists in simply mixing the gold nanoparticle colloid with an acidic aqueous indium-111 chloride solution.…”

Section: Resultsmentioning

confidence: 99%

The biodistribution of gold nanoparticles designed for renal clearance

Alric¹,

Miladi²,

Kryza³

et al. 2013

Nanoscale

123

124

View full text Add to dashboard Cite

Owing to their tunable optical properties and their high absorption cross-section of X- and γ-ray, gold nanostructures appear as promising agents for remotely controlled therapy. Since the efficiency of cancer therapy is not limited to the eradication of the tumour but rests also on the sparing of healthy tissue, a biodistribution study is required in order to determine whether the behaviour of the nanoparticles after intravenous injection is safe (no accumulation in healthy tissue, no uptake by phagocytic cell-rich organs (liver, spleen) and renal clearance). The biodistribution of Au@DTDTPA nanoparticles which are composed of a gold core and a DTDTPA (dithiolated polyaminocarboxylate) shell can be established by X-ray imaging (owing to the X-ray absorption of the gold core) and by magnetic resonance imaging (MRI) since the DTDTPA shell was designed for the immobilization of paramagnetic gadolinium ions. However scintigraphy appears better suited for a biodistribution study owing to a great sensitivity. The successful immobilization of radioelements ((99m)Tc, (111)In) in the DTDTPA shell, instead of gadolinium ions, renders possible the follow up of Au@DTDTPA by scintigraphy which showed that Au@DTDTPA nanoparticles exhibit a safe behaviour after intravenous injection to healthy rats.

show abstract

Section: Resultsmentioning

confidence: 99%

The biodistribution of gold nanoparticles designed for renal clearance

Alric¹,

Miladi²,

Kryza³

et al. 2013

Nanoscale

123

124

View full text Add to dashboard Cite

show abstract

“…In addition, no TcO 2 •2H O was detected in anoxic AGW, as would be expected if cations displaced Tc(IV) from DTPA. These two findings suggest that use of the Tc-DTPA stability constant of Levin et al (1980) does not adequately describe the behavior in our system, potentially because of the much lower Tc/DTPA ratios. By contrast, bacterial cell surfaces are predominantly negatively charged at this pH (Fein et al, 1997;Sokolov et al, 2001).…”

Section: Discussionmentioning

confidence: 92%

“…The thermodynamic equilibrium constant (log K) of equation 1 has been determined to be 26.3 (Levin et al, 1980). DTPA is a strong chelator of metal cations; as an example, it is added to paper pulp liquors before bleaching with peroxide to prevent iron oxidation (Holzbecher et al, 2005).…”

mentioning

confidence: 99%

“…The database was supplemented with equations 1 and 3. The formation constant of equation 1 was taken as published byLevin et al (1980). However, the stability constant of equation 3 is uncertain, not only because the reactivity of Fe(III) (hydr)oxides varies depending on mineralogy, but also because the acidity of the systems studied here (pH 7.1) is close to the point of zero charge of Fe(III) (hydr)oxides.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Chemical stability of 99mTc–DTPA under aerobic and microbially mediated Fe(III)-reducing conditions in porous media

Slowey

Vandehey

O’Neil

et al. 2014

Applied Radiation and Isotopes

View full text Add to dashboard Cite

(99m)Tc-DTPA has been used as a conservative tracer to quantify water transport through porous media. However, more information on the reactivity of this (99m)Tc compound under varying geochemical conditions is desirable to better understand its potential uses. We measured the speciation of Tc following amendment of (99m)Tc-DTPA to batch systems spanning a range of controlled biogeochemical conditions. Our results suggest that (99m)Tc-DTPA is stable under the reducing conditions tested. However, freshly precipitated Al-ferrihydrite may displace Tc(IV) from DTPA in the absence of Fe(III)-reducing conditions.

show abstract