The St. Kitts Vervet (Cercopithecus aethiops)

Mt, McGuire

doi:10.1159/000460030

Cited by 27 publications

(37 citation statements)

References 11 publications

(28 reference statements)

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“…11,32 Early reports considered vervets 13 years of age as elderly 6 ; however the life expectancy of vervets in captivity has been revised such that animals above 20 years of age are now considered elderly. The 26 year old animal in the current report represents the oldest female vervet monkey originating from this colony.…”

Section: Methodsmentioning

confidence: 99%

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

Plate

Bates

Mannava

et al. 2013

Journal of Shoulder and Elbow Surgery

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Background Non-human primates have similar shoulder anatomy and physiology compared to humans and may represent a previously underutilized model for shoulder research. This study sought to identify naturally occurring bony and muscular degeneration in the shoulder of non-human primates and to assess relationships between structural and functional aspects of the shoulder and measures of physical function of the animals. We hypothesized that age-related degenerative changes in the shoulders of non-human primates would resemble those observed in aging humans. Methods Middle-aged (n=5, ages 9.4 to 11.8 years) and elderly (n=6, ages 19.8 to 26.4 years) female vervet monkeys were studied for changes in mobility and shoulder function, and radiographic and histologic signs of age-related degeneration. Results Four out of six (4/6) elderly animals had degenerative changes of the glenoid compared to 0/5 of the middle-aged animals (p=0.005). Elderly animals had glenoid retroversion, decreased joint space, walked slower and spent less time climbing and hanging than middle-aged vervets (p<0.05). Physical mobility and shoulder function correlated with glenoid version angle (p<0.05). Supraspinatus muscles of elderly animals were less dense (p=0.001), had decreased fiber cross-sectional area (p<0.001), but similar amounts of nuclear material (p=0.085). Degenerative rotator cuff tears were not observed in any of the eleven animals. Discussion and Conclusion The vervet monkey naturally undergoes age-related functional, radiographic and histological changes of the shoulder and may qualify as an animal model for selected translational research of shoulder osteoarthritis. Level of evidence Basic Science Study, in-vivo Animal Model

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Section: Methodsmentioning

confidence: 99%

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

Plate

Bates

Mannava

et al. 2013

Journal of Shoulder and Elbow Surgery

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“…The VRC was founded in 1975 as a facility jointly managed by the University of California, Los Angeles, and the Department of Veterans Affairs. The founder animals (28 males, 29 females) were wild caught from 1975 to 1983 in St. Kitts, West Indies, as described in McGuire 9 and Fairbanks et al 2 The current population consists of approximately 530 descendants with 24 of the original matrilines now in their second to eighth generation. For clarity, the animals of interest-Nos.…”

Section: Materials and Methods Animalsmentioning

confidence: 99%

Clinicopathologic Characterization of Naturally Occurring Diabetes Mellitus in Vervet Monkeys

Cann¹,

Kavanagh

Jorgensen

et al. 2010

Vet Pathol

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Diabetes mellitus (DM) is a group of chronic metabolic diseases characterized by persistent fasting hyperglycemia, and it can be of either polygenic or monogenic origin. Animal models have played an important role in elucidating the pathophysiology of the polygenic Type 1 and type 2 DM forms; however, useful animal models of the monogenic forms do not exist. The authors describe 4 cases of naturally occurring DM in vervet monkeys (Chlorocebus aethiops sabaeus), 1 of which has clinicopathologic findings consistent with type 2 DM, including persistent hyperglycemia, hypertriglyceridemia, islet amyloidosis, and reduced islet insulin immunostaining. In contrast, the 3 remaining animals have clinicopathologic similarities to a monogenic form of the disease, including a lack of islet amyloidosis and hypertriglyceridemia, as well as normal islet insulin immunostaining. In addition, pedigree analysis conducted on one of these animals is consistent with either an autosomal dominant or mitochondrial inheritance pattern, which supports a monogenic form of DM. The authors thus hypothesize that a naturally occurring monogenic form of diabetes may occur in vervet monkeys, making them a potential animal model for future studies.

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“…Data from longitudinal studies of Old World monkeys indicate that the interbirth interval (IBD varies considerably depending on environmental circumstances [Altmann, 1980;Strum and Western, 1982;Mori, 1979;Hall and Gartlan, 1965;McGuire, 1974;Cheney et al, 19811. The upper limit to this range of plasticity appears to be one infant per year for most macaque species that have been maintained in provisioned captive populations [Wilson et al, 1978;Hadidian and Bernstein, 1979;Drickamer, 1974;Silk et al, 19811.…”

Section: Introductionmentioning

confidence: 99%

Determinants of fecundity and reproductive success in captive vervet monkeys

Fairbanks

McGuire

1984

American J Primatol

104

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Between 1975 and 1983, adult female vewet monkeys (Cercopithecus aethiops sabaeus) over 3.5 years of age, living in two undisturbed social groups in a captive colony in Sepulveda, California, have averaged 1.0 births per female year with a mean interbirth interval of 10.7 months. Increased fecundity did not result in decreased survival rates of offspring in this population. Fecundity was influenced by the mother's age and dominance rank. The primary factor in the age-fecundity relationship was the age at first birth, which varied from three to five years. High-ranking females contributed the most to the high rate of fecundity, with significantly shorter interbirth intervals, more births per female year, and more surviving infants compared to low-ranking females.

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The St. Kitts Vervet (Cercopithecus aethiops)

Abstract: Vervet monkeys were brought to the Caribbean island St. Kitts three centuries ago and have lived there since in different ecological niches. Their distribution, characteristics and research value are described.

Cited by 27 publications

References 11 publications

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

Clinicopathologic Characterization of Naturally Occurring Diabetes Mellitus in Vervet Monkeys

Determinants of fecundity and reproductive success in captive vervet monkeys

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