“…Of the three main causes of spontaneous hypoglycaemia mentioned by Conn (1940)-hepatogenic hypoglycaemia, functional hyperinsulinism or cryptogenic hypoglycaemia (found in persons of unstable personality and almost always associated with psychoneurotic symptoms), and organic hyperinsulinism from an adenoma or carcinoma of islet tissue -the first two could be excluded. There was no clinical evidence of hepatic insufficiency and the glucose-tolerance test did not show the high plateau curve characteristic of liver disease.…”