The Spontaneous Hypertensive/NIH-corpulent Rat: A New Rodent Model for the Study of Non-insulin-dependent Diabetes Mellitus and Its Complications

Modulation of carbohydrate metabolism and peptide hormones by soybean isoflavones and probiotics in obesity and diabetes

“…The SHR/N-cp rat is a genetic animal model of obesity and type II diabetes mellitus and exhibits many feature characteristics of the insulin resistance syndrome, namely glucose intolerance, hyperinsulinemia, hypercholesterolemia, hypertriglyceridemia and mild hypertension [29][30][31][32]. The purpose of this study is to determine the effects of soy isoflavones on glucose and triglyceride metabolism and the hormones influencing their metabolism.…”

High lipolytic activity and dyslipidemia in a Spontaneous Hypertensive/NIH Corpulent (SHR/N-cp) rat: a genetic model of obesity and type 2 diabetes mellitus

“…Similar abnormalities in the lipid profile associated with obesity, insulin resistance, glucose intolerance and type 2 diabetes have already been described in other models of obesity, although they were less important than those noted in obese SHR/N-cp rats (4, 9, 18). The severity of the lipid abnormalities in the obese corpulent rat that presumably contributes to the development of diabetes may explain the fact that this particular strain dies at very early age (about one year-old), mainly from cardiovascular complications resulting for atherosclerotic lesions (16,21). It should be pointed out that the presence of such metabolic disorders in corpulent diabetic SHR/N-cp rat is similar to the well known lipid perturbations that are frequently observed in obese humans (5, 7, 13).…”

“…Insulin resistance is a characteristic feature of numerous animal models of obesity (9, 18), and more particularly of the obese SHR/N-cp (SHR = spontaneous hypertensive rat; cp = corpulent; NIH inbred strain). This strain has been obtained twenty years ago by crossing a SHR/N-rat (which was hypertensive) with a Koletsky rats, followed by an extensive backcrossing to SHR rats in order to achieve congenicity (10, 16,21). Frank diabetes appears at a very early age in obese SHR/N-cp rats (two months-old) and animals remain markedly hyperinsulinemic and insulin resistant until they die from cardiovascular complications associated with diabetes.…”

Renal lesions in leptin receptor-deficient medaka (<i>Oryzias latipes</i>)

“…Although the ZDF rat and the cp / cp rat are also animals with leptin-receptor deficiency and exhibit hyperglycemia, some of these rats do not always show hyperglycemia, and in others, glucose tolerance improves with aging 10 , due to the high ability of their islet beta-cells to secrete insulin, which is an innate characteristic of rats 11 . To use rats as a model of DN, rats that are congenitally hypertensive 10 or have undergone transgenic modification must be used 12 . Since there are also various differences in metabolism and compensatory functions among mouse strains, they show different characteristics of DN 5 .…”