The spontaneous burst activity of peripheral blood monocytes in patients with acute polyradiculoneuritis, lymphocytic meningoencephalitis, and multiple sclerosis

Hammann, Klaus P.; Röder, R.; Buddenberg, D.; Corradini, Claudio; Pfeifer, Ben; Hopf, H. C.

doi:10.1016/0022-510x(86)90016-x

Cited by 8 publications

(1 citation statement)

References 13 publications

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“…The low serum ubiquinone level may possibly reflect an increased liver catabolism, by an NADPH-dependent cytochrome P-450 system (EC 1.6.2.4). Finally, the respiratory burst activity of phagocytosis, which appears to be disturbed in some way in multiple sclerosis (23), is dependent on an NADPH oxidase (24).…”

Section: Discussionmentioning

confidence: 99%

Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH

Steen¹,

Axelsson²,

Bowallius³

et al. 1987

Acta Neurologica Scandinavica

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Genetic predisposition in MS, influence of fat consumption on the disease, and excretion of lipid metabolites in urine led us to investigate isoprenoid metabolism in this disease. Ubiquinone concentration and biosynthesis was normal in lymphocytes. Cytochrome oxidase, which contains an isoprenoid side chain, was normal in activity. Cholesterol biosynthesis from acetate was found to be elevated in MS, and so was triglyceride biosynthesis. Increased biosynthesis may offer a very simple explanation to all the metabolites excreted (3-methylglutaconic acid, 2-hydroxy-2-methyl-3-butenoic acid and adipic acid). Increased biosynthesis may be caused by an elevated NADPH/NADP ratio, since such an elevation may also account for many other biochemical anomalies in MS. Elevated NADPH/NADP ratio may be of direct importance in the pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH

Steen¹,

Axelsson²,

Bowallius³

et al. 1987

Acta Neurologica Scandinavica

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Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

Selmaj

Raine

1988

Annals of Neurology

1,304

503

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Recombinant human tumor necrosis factor (rhTNF) has been tested for its effect on myelinated cultures of mouse spinal cord tissue. As controls, recombinant human interferon gamma (rhIFN) and interleukin-2 (rhIL-2) were tested, as well as T-cell supernatants, antigalactocerebroside serum, and normal culture medium. It was found that rhTNF induced delayed-onset (18-24 hr) oligodendrocyte necrosis and a type of myelin dilatation peculiar to this system. Some nerve fibers progressed to demyelination by 72 hours. The myelin dilatation was not reversible by return to normal feeding solution for 3 days. In contrast, rhIFN, rhIL-2, T-cell supernatants, and normal medium had little or no effect on cultures. This mechanism differs from other immune-mediated mechanisms in that it appears that a physiological (not structural) demyelination occurs initially without overt destruction of the myelin sheath. These observations are relevant to the evolution of the multiple sclerosis plaque: dysfunction of ionic channels might contribute to the eventual demise of oligodendrocytes and axons in the longstanding lesion.

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Die Wertigkeit der spontanen Chemilumineszenz-Aktivität peripherer Blutmonozyten als Verlaufsparameter von Entzündungsreaktionen — Eine vergleichende Betrachtung

Hammann¹

1989

Verhandlungen Der Deutschen Gesellschaft Für Neurologie

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The spontaneous burst activity of peripheral blood monocytes in patients with acute polyradiculoneuritis, lymphocytic meningoencephalitis, and multiple sclerosis

Cited by 8 publications

References 13 publications

Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH

Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

Die Wertigkeit der spontanen Chemilumineszenz-Aktivität peripherer Blutmonozyten als Verlaufsparameter von Entzündungsreaktionen — Eine vergleichende Betrachtung

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