The spongy state: A form due to the agonal or postmortem evolution of gaseous carbon dioxide from glycogen

Improved method for fixation of dog brain by vascular perfusion

“…7) and (to a lesser extent) in the cerebellar cortex. These are thought to be produced by the agonal or post-mortem evolution of carbon dioxide by degradation of glycogen (Feigin and Budzilovich, 1966-67). Fig.…”

Infantile spongy degeneration of the central nervous system associated with glycogen storage and markedly fatty liver

“…Feigin and his colleagues (Feigin and Budzilovich, 1966;Feigin, Pena, and Budzilovich, 1968) have indicated that spongy change in the central nervous system (CNS) could result from the evolution ofgaseous carbon dioxide in the tissue, preterminally or shortly after death, and that this carbon dioxide is formed by the breakdown of glycogen presumably deposited in the affected tissue as a consequence of the underlying disease state with subsequent decarboxylation of its products. Thus, they considered that the status spongiosus does not reflect the pathological anatomy of a disease process present in life and may not be a valid basis for delineating a nosological entity.…”