The splicing factor PTBP1 promotes expression of oncogenic splice variants and predicts poor prognosis in patients with non-muscle invasive bladder cancer

Abstract

Translational relevance PTBP1 expression positively correlates with NMIBC progression and with worse clinical outcome of patients. Mechanistically, PTBP1 regulates pro-survival features and modulates alternative splicing of bladder cancer-related genes in NMIBC cell lines and patient specimens. Thus, PTBP1 expression and its splicing signature can represent novel outcomepredictor markers for NMIBC.

Immunological significance of alternative splicing prognostic signatures for bladder cancer

“…SFs play a carcinogenic or inhibitory role by participating in abnormal AS events in BLCA [71,72]. Consequently, we constructed an AS-SF regulatory network of BLCA to visually demonstrate the abnormal AS regulatory mechanism of BLCA.…”