The splicing factor PTBP1 promotes expression of oncogenic splice variants and predicts poor prognosis in patients with non-muscle invasive bladder cancer
Abstract:Translational relevance PTBP1 expression positively correlates with NMIBC progression and with worse clinical outcome of patients. Mechanistically, PTBP1 regulates pro-survival features and modulates alternative splicing of bladder cancer-related genes in NMIBC cell lines and patient specimens. Thus, PTBP1 expression and its splicing signature can represent novel outcomepredictor markers for NMIBC.
“…SFs play a carcinogenic or inhibitory role by participating in abnormal AS events in BLCA [71,72]. Consequently, we constructed an AS-SF regulatory network of BLCA to visually demonstrate the abnormal AS regulatory mechanism of BLCA.…”
“…SFs play a carcinogenic or inhibitory role by participating in abnormal AS events in BLCA [71,72]. Consequently, we constructed an AS-SF regulatory network of BLCA to visually demonstrate the abnormal AS regulatory mechanism of BLCA.…”
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